J4G4J8 · J4G4J8_9APHY

  • Protein
    HECT-type E3 ubiquitin transferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

136285001,0001,5002,0002,5003,0003,500
TypeIDPosition(s)Description
Active site3595Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionubiquitin protein ligase activity
Biological Processprotein polyubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HECT-type E3 ubiquitin transferase
  • EC number

Gene names

    • ORF names
      FIBRA_03206

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TFFH 294
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Fibroporiaceae > Fibroporia

Accessions

  • Primary accession
    J4G4J8

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region211-250Disordered
Compositional bias214-250Polar residues
Region731-769Disordered
Compositional bias741-769Polar residues
Region974-1020Disordered
Compositional bias977-1020Polar residues
Domain1290-1330UBA
Region2020-2167Disordered
Compositional bias2032-2047Acidic residues
Compositional bias2069-2167Acidic residues
Region2297-2317Disordered
Compositional bias2298-2317Polar residues
Region2464-2561Disordered
Compositional bias2470-2490Basic and acidic residues
Region2948-2994Disordered
Compositional bias2950-2965Polar residues
Domain3293-3628HECT

Sequence similarities

Belongs to the UPL family. TOM1/PTR1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,628
  • Mass (Da)
    399,835
  • Last updated
    2012-10-31 v1
  • Checksum
    B70A53C06B6F4871
MRITHKAKRPLTPLPQVAELITKLHDTPNEELHEVLSQMDAWRWPRSDLNAWIKVLNKFDAILEEVIRDYDLDKLQINVFTPVTKKTVCEILRFERLLLENSTNRKTFNSYDRLNSLMLTSDLDVLILTLNLLLRPAQQYSSQPAVLHALSISTPRLTSLARRWSNLREYDINLVDLVTEKGKPQVEALPTEAREVNFTFYKNEKLPLPTYKDKGQSSEVQMTDVVPQTPTRKGGASSGAGSTAQGSSSGAVIVHIESSTIESKEPMDILADAMEMYSVPDDEKFELLTRIRTARALTPAYSSDREKLVMIRLLATAIFGHTHVESQAQSMLFLYEPDMITHIAELLQLDRDVDVQVQNVAIAALDSLGRYRNKIQDVLTAVNAGVNHGVLMALLRKTVVDVAQPTSTLPQFFVESLLSFVTFVATHASGGNMVVGAGLVPLLIQVIENRLPNRLYVVSKTMQLLDNVLYGFNNAFQLFCNGRGVEVLVDRIEYEVELDLAQCSTEEPSREVVISFGKLLVPRAAVLKHTLRSMHRMMQSSGTAEGLRGLLDSSLLRSAKKIMENRTVFGPSILPIVINIMATFVHNEPTCLSVIQEAGLPEVFYGVVESGVEPVIEVIQSIPNAIGALCLNQAGQDQLTARPYIIPGLLSIFTSERHQRILQDKENAVLIGTAIEELIRHHPSLKQAVFNAIKAIMDNIYQMGNDYVPDEDMKQWYLLLLNSPSQSAKEATMDADVDMASAETAQSQRSAPTNSQGGSINDAASLPGDDSSGSHDNIIVSFIDVFGKFLEGFFQCIPHCRDFVTDEEALSRFGKLTALPCLPYDFVNSLASDSLVQVVRTMAEVAPGETVSFLVRLVHESLASTKNFWSSMREESELLQLVNVSDRELQRGNDRVRQYITLYIRTSLLSDIYSTAGYSHGRATATLLQSLTGPSAHNILPDLGALHRTCVWENIMLKSGLALQGVDVPAPADVTALDPHSSSTVTPTDTPPISQDTSAHTLPSTANGAQGESSVPVASDSVTVKDNSAKLQNAKIAKHLASQLPTCLAPFFQGKADLLLGRNTDSAQKQKIQETSLILADILVKHLDLHTVADKMSVYAYHTVMLGLSTILLVDERAAQKTLYTVLLAAFSRAGGIDAILRLCNTFVHAIKTMTDVSPEDRSHVAKEELVHAYGGLKVALHLLHPVLSAKPLFDSTQTTLLVSSEKKDSDPDYFEPRQFLVRTRIAAMPLLADLWGASWLSSAPLGVSKSVVNVLMDVLSMDGEEAKDPPQGGAPSLMSNGFAIARPAGPDENRIRQLVDMGFPRSAAERALVRTRNNVNAATELLLAHPFPLPPDPEPQEPPVAADAPIETSGEVTAGAGTEAEVPASSVADEQASSVPVKSTEDWIKELNALRDPLKDTMGRQALRLLDEHPSLAFDVQKVFVGPSNGYREQAALLLIDDVKSLSSSAYDVQEQSMAVRCRLLALALNDPTSPLTQMIDSDANNLMDSMLALLLSNPTNIEGHPTVPKWLAAHLLVAEALLTLGEEPRSISVPKENEAIVQESLSVGRDHSEAKNILFDFCLRLLALSTISKDDLLSALRLFVYLTRDHKMAEKFVHRDGLVLLFRYMQISAGTQSAAGIQSHIAIILRHIVEDQSILQHVMRQEIKRFFAHPRHRVLDVGNYVTGCGALALRDPSTFINVTQELCQLSQPYSNSKSISLRAEVKSEAPVTNKGSDMHIDDPFTTHTQTLPDLEAPVHFLIAELMRSLKRGGAPETSSAEMPKMAGSEAGVLDGPSEPSANALKPETIEPSSLLEDDYVYSCFLMQCLSELLFSYDACKIAFLSFSPKRRTQIPAKDVGMKHRTAAIQFLLMELVTFGTIDPQPSSEARKRIMLCNWAMSVVVALCVDTSLTHDIKDVPAELISVRKFVLEAISRALKDLPASEPPELRYSRLLALADLCNRLLTVRFNSNTRKPHEEAPTHIAKVMLEKNFVATLTNALAEVDLNYPNIRGVVTGLLRPLNFLSKIAIKMSRVSDKSKESLDEKVEDVESVSSEEDDTTEHDGDETPDLYRNSSLGLFGGEMEDVNFGPDDDMDEDGEEADEDVDMDFGDETGSEDTSHTDDDVEDDIENAIENETDEDDDDDEESWQDEEEEEEEGLVANDGGDPEEIGDEEEEEEGEGDDGEDVMWQSIAVADDLVDGAADEGDDDEDPVPIMPMDADEEADMASEEDEYGDELGVAGHGPIGGNVFELATAGFANVLNGGAVNATRIAPPILWADPTRSGRRRGIDDDMDIFSRIRNAPISSDAATHPLLVDPATNSTRGSTGQARSTRRFQRNVIATNNPHDLLQTIEDAIGEGALQLFQHIVSHQRGGGGETIRIDVPSGTLGPLQRHGRGTISASIRLERAPRSGDTRSDSHNLDPLLTVQRWLEEVKMVHGKFEQARLSKLSNHVNVVLMPAAVEAAKQAKLVEEEAARQAEEQAQVDQAAAKEQEEAERARVEQERLQLDSEVAQGPDVDPEQQGSMSVDGDTDMVDVSQDAPIEPDESQDTQDTTQDDSAVVAEDGPAAEASSSGAQRITVMIHGSPVDITETGIDPTFLEALPDDMREEVLNQHVRDQRAARVERPADSHISPEFLDALPPELRAEILQQESIERARQQVTTAQQGGGGVPADIDPASFIASLDPHLRQVVLMDSDDGLIQSLPSHILAEAGIHRENARQARAQPLANAEVRPATTQHSQKTAVSRDAIQLLDKSAVAVLVRLLFFPHTLKKNLLYKVLVNLCENSKTRTDLFNLLLNILQDGSGDLASIDRSFAQMSVRNSKQPHTLTPKSVGKQRVASDYLGTLALSPGHNEIIPELIVQRCLEALTYIVSANELSSLFFLTEHELPLGLRRTASKKGKGKEKQVPQTHYPVVLLLSLLDRPSILRTSSIVESVVTLLATITRPLASLKDFNKGKPETQDLMEASAPSAAQSVVVPSESIDTSAPAEEPAADDQTVEAGQGPSSEEKVLLARPPVIPHTVMRFIVNILTAGECSGRTFSQSLALIQHLSFVPDARDIIANELRSRAQDFGQSLFTALDELAIALHESQGEVLASSIASKFSPASSDQAKLLRVLKTIDYMYSPRSTSSPSSAVSDADVEKVQGIYESFRFAPLWQRLGDCLSFIEEKPETEHIATVLLPLIESLMVVCKYVGAKSAAGSVARILRASASPRSPTSTRETMEELFVTFTDAHRKVLNLMVRNNPSLMSGSFSLLVHNPRVLDFDNKRNYFSQQLHRRPHAREHHGTLQLNVRRPRVFEDSFQYLQRKTGDQIKYGKLSVRFYEEEGVDAGGVTREWFQILARQMFDPNYALFQPCAADRLTYQPNKASWVNPEHLSFFKFVGRVIGKAIYDGRLLDAYFARSLYRQILAKPVDYRDVEWVDPEYYNSLCWILDNDPSALELTFSVEADEFGVTKIVDLRENGRSVAVTQENKREFVQLSAQYRLYSSIKDQIEALLTGFYEIIPKDLIAIFNEQELELLISGTPDIDVDEWRAATEYNGYTSSDPVIVWWWRALKSFNREERAKVLSFATGTSRVPLGGFTELQGVQGVQRFSIHRAYGDQDRLPQAHTCFNQIDLPQYSSYEMLRQQLLLAINEGGEGFGFA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias214-250Polar residues
Compositional bias741-769Polar residues
Compositional bias977-1020Polar residues
Compositional bias2032-2047Acidic residues
Compositional bias2069-2167Acidic residues
Compositional bias2298-2317Polar residues
Compositional bias2470-2490Basic and acidic residues
Compositional bias2950-2965Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE797020
EMBL· GenBank· DDBJ
CCM01158.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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