J3TNZ7 · J3TNZ7_9POLY

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for dna binding.

170250100150200250300350400450500550600650700
TypeIDPosition(s)Description
DNA binding142-258T-ag OBD

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionATP binding
Molecular FunctionDNA replication origin binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA replication
Biological Processsymbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large T antigen
  • EC number
  • Alternative names
    • DNA 3'-5' helicase large T antigen

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A504
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae > Alphapolyomavirus > Alphapolyomavirus tertarplanisrostris

Accessions

  • Primary accession
    J3TNZ7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Expression

Keywords

Interaction

Subunit

Forms homohexamers in the presence of ATP. Interacts with host HDAC1. Interacts (via LXCXE domain) with host RB1; the interaction induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Interacts (via LXCXE domain) with host pRB-related proteins RBL1 and RBL2. Interacts (via C-terminus) with host TOP1 and POLA1 allowing DNA replication. Interacts with host preinitiation complex components TBP, TFIIA and TFIID to regulate transcription initiation.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain12-67J
Region114-135Disordered
Domain142-258T-ag OBD
Domain270-362T-ag D1-type
Domain405-564SF3 helicase
Region640-702Disordered
Compositional bias643-661Pro residues
Compositional bias662-702Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    702
  • Mass (Da)
    80,421
  • Last updated
    2012-10-31 v1
  • Checksum
    4EC288CB68F117FF
MDKALNREESQELMQLLGLSMTLYGQLPMMRKAYLNKCKEYHPDKGGDEQKMKRMNELYKKLEDALSAASREETVWTSWASGECPTYGSAEWDAWWREFNADWEENLRCDEEMPDFDEDNTQSSQHTPPKKKFRRDAPSEFPEVLLEFLSKAVFSNKCVSAFLIYTTKEKSVLLYRKVWDKFSSTFISRHSHGADKALLYVLTPNKHRVSAINNFCKKFCSISFVLVKAIIKPFPCYCALGKEPFELLDESVPGGLTENVFMAEDCEEGQKQVNWKQISDYACAIKCDDVHLLMGLYLEFEFPVESCGKCDKQVLPSHFKYHKDHLENAKLFAQCKNQKSICQQAVDAVIAKKRVDQLVLTRKQMLTERFVTMLDKMDAHFGPRGAGDLREYMAGVCWLHCPIHNIEEHIVEFLQCIVSNVPKRRYWLFKGPVNSGKTTLAAALLDLVGGKALNINLPFERINFELGVAIDQYMIVFEDVKGTVSTKDLPQGLGLSNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYVLPTTLSIRFVKTLNFRVKNYLSKSLRQTEELLEKRILQSGMTLMLMLVHHCLVQEFDPSIQARVVEWKERLDREVGDDEMNTFLRRIAQGKYILEDEEEDLMDLDQQRMPPPPPRGPPPPYTPVDPLSTAQSQQSQSDESQGSQPTTPATSQSTAPDSGIFFESPQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias643-661Pro residues
Compositional bias662-702Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ958890
EMBL· GenBank· DDBJ
AFP94199.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help