J3TNZ7 · J3TNZ7_9POLY
- ProteinLarge T antigen
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids702 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 142-258 | T-ag OBD | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA replication origin binding | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication | |
Biological Process | symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge T antigen
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae > Alphapolyomavirus > Alphapolyomavirus tertarplanisrostris
Accessions
- Primary accessionJ3TNZ7
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Keywords
- Developmental stage
Interaction
Subunit
Forms homohexamers in the presence of ATP. Interacts with host HDAC1. Interacts (via LXCXE domain) with host RB1; the interaction induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Interacts (via LXCXE domain) with host pRB-related proteins RBL1 and RBL2. Interacts (via C-terminus) with host TOP1 and POLA1 allowing DNA replication. Interacts with host preinitiation complex components TBP, TFIIA and TFIID to regulate transcription initiation.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 12-67 | J | |||
Region | 114-135 | Disordered | |||
Domain | 142-258 | T-ag OBD | |||
Domain | 270-362 | T-ag D1-type | |||
Domain | 405-564 | SF3 helicase | |||
Region | 640-702 | Disordered | |||
Compositional bias | 643-661 | Pro residues | |||
Compositional bias | 662-702 | Polar residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length702
- Mass (Da)80,421
- Last updated2012-10-31 v1
- Checksum4EC288CB68F117FF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 643-661 | Pro residues | |||
Compositional bias | 662-702 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JQ958890 EMBL· GenBank· DDBJ | AFP94199.1 EMBL· GenBank· DDBJ | Genomic DNA |