J3QR65 · J3QR65_HUMAN
- Proteinphosphatidylinositol-3,5-bisphosphate 3-phosphatase
- GeneMTMR4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1138 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 320-323 | substrate | |||
Binding site | 345-346 | substrate | |||
Active site | 407 | Phosphocysteine intermediate | |||
Binding site | 407-413 | substrate | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | dephosphorylation | |
Biological Process | phosphatidylinositol biosynthetic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephosphatidylinositol-3,5-bisphosphate 3-phosphatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionJ3QR65
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Peripheral membrane protein
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,029 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 8 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 541 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 544 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 551 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 553 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 559 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 570 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 572 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 904 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 945 | PRIDE | Phosphoserine | |||
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 153-594 | Myotubularin phosphatase | |||
Domain | 376-420 | Tyrosine specific protein phosphatases | |||
Region | 588-636 | Disordered | |||
Compositional bias | 593-607 | Polar residues | |||
Region | 652-699 | Disordered | |||
Compositional bias | 723-741 | Polar residues | |||
Region | 723-744 | Disordered | |||
Compositional bias | 770-797 | Polar residues | |||
Region | 770-820 | Disordered | |||
Domain | 1057-1117 | FYVE-type | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,138
- Mass (Da)126,671
- Last updated2012-10-03 v1
- ChecksumBE906F467F09F8F4
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9NYA4 | MTMR4_HUMAN | MTMR4 | 1195 | ||
J3KT95 | J3KT95_HUMAN | MTMR4 | 112 | ||
A0A804HJV7 | A0A804HJV7_HUMAN | MTMR4 | 1209 | ||
J3QKV8 | J3QKV8_HUMAN | MTMR4 | 95 | ||
J3QRJ2 | J3QRJ2_HUMAN | MTMR4 | 98 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 593-607 | Polar residues | |||
Compositional bias | 723-741 | Polar residues | |||
Compositional bias | 770-797 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005666 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |