J3NNW5 · J3NNW5_GAET3

Function

function

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site423Proton donor/acceptor

GO annotations

AspectTerm
Cellular ComponentNuA4 histone acetyltransferase complex
Cellular Componentpericentric heterochromatin
Cellular Componentsite of double-strand break
Cellular ComponentSwr1 complex
Molecular Functionhistone H3K4 acetyltransferase activity
Molecular Functionhistone H4K16 acetyltransferase activity
Molecular Functionpeptide butyryltransferase activity
Molecular Functiontranscription coregulator activity
Biological ProcessDNA repair
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processnegative regulation of DNA-templated transcription
Biological Processpositive regulation of heterochromatin formation
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone acetyltransferase
  • EC number

Gene names

    • Name
      20343429
    • ORF names
      GGTG_02971

Organism names

Accessions

  • Primary accession
    J3NNW5

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Component of the NuA4 histone acetyltransferase complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-24Disordered
Compositional bias87-102Basic and acidic residues
Region87-147Disordered
Region194-245Disordered
Compositional bias204-234Basic and acidic residues
Domain247-521MYST-type HAT

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    60,185
  • Last updated
    2012-10-03 v1
  • Checksum
    7126578AE14CC341
MSLHATAGDGAAVGSSEPRQKGRATADTLLVGCIAWVEKEGQPRRAEILSIKETKSGRQFYCNFDNFNKRLDEWVPLARIDLARDVEWPNPDKDKPKDSKVSKKGASSGQPSKKNQPLKRGQKRPIGKREQSVVSEAGTPTTAHPWSDFVESQGQLKTPLAETPVAATPGDDAGDDRLIPAGQPASAAVAVVTPGGVSDDMDTTAVGDDDKAGGGGKADGHPSFSREEEIEKLRTSGSMTQNPTEVSRIRNISKIQFGKFDLYPWYFSPYPEAFSMEDVIFICEFCLCYYGDPKSFARHRRKCTLQHPPGNEIYRDEHVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTTKDDKGDHLVGYFSKEKESADGYNVACILTLPQYQRKGFGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWSEMIMDLLISYHERDERCSIESVAAQLSMTTQDVEHTLQALRMQAYHKGEHKIVVPEKLLEMREKSKTKQKRVIDPDRIQWKPPVFTAASRTWGW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias87-102Basic and acidic residues
Compositional bias204-234Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL385396
EMBL· GenBank· DDBJ
EJT77868.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help