J3LV62 · J3LV62_ORYBR

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site349-354ATP (UniProtKB | ChEBI)
Binding site375a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site396-398a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site423-426a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site430CMP (UniProtKB | ChEBI)
Binding site462ATP (UniProtKB | ChEBI)
Binding site466a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site477a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site505ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast stroma
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Organism names

  • Taxonomic identifier
  • Strain
    • IRGC 101232
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza

Accessions

  • Primary accession
    J3LV62

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil65-92

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    523
  • Mass (Da)
    59,481
  • Last updated
    2012-10-03 v1
  • Checksum
    3C6B6F8DC5627259
MAWQDNAATQPNRCGMAWQAFWPRQCGWRGQKVYVVEIFFPKDPEGVLGPPQGGHIARLEFRRRLDRDSDAREAFQRQVREEQERRRQEREARVIPDTDAGLVEFFLDTEAREIEVEIARLRPRLNQPFFDYIQRELAQIKFAITRTAEMEDRLIELEAMQKVLLEGVEAYDKLQNDLVTAKERLTKILQSSDKKSTLLEMVERNELNMSILTLLDENIASARTSNQEEAVAFMENVRTSILKYITWKKMASQLNCESVIYATGVSSTVMASQKRELRLWFTVAVCDLYECGISYSVRCDDACCYRSCFSNKVCLPFVALLVRLNTEGGGDGGANSCRPFIAFVLGGPGSGKGTQCARIASDFGFAHLSAGDLLRHEISSGSDKGQMILDIIKEGRIVPSEITVELIRKAMETTDAKRVLIDGFPRCEENRIAFERITGTEPDLVIFFDCPEDEMVKRLLGRNQGRVDDNIETIKKRLKVFDNLNIPVVDYYSSRGKVHKIDATGTEEEIFGAVRNLFASLRF

Keywords

Genome annotation databases

Similar Proteins

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