J3K6D3 · J3K6D3_COCIM
- ProteinD-xylose reductase [NAD(P)H]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids331 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Catalytic activity
- NAD+ + xylitol = D-xylose + H+ + NADH
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 57 | Proton donor | ||||
Sequence: Y | ||||||
Site | 85 | Lowers pKa of active site Tyr | ||||
Sequence: K | ||||||
Binding site | 118 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aldose reductase (NADPH) activity |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameD-xylose reductase [NAD(P)H]
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Onygenaceae > Coccidioides
Accessions
- Primary accessionJ3K6D3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-300 | NADP-dependent oxidoreductase | ||||
Sequence: GLGTFQVDPSLYPEGSVKDSVLHALKIGYRHIDAALAYGWGSVERGIGAAIRASGVPREDVFVVTKLHNCFHAPEDVEVGMNMSLKNLGLGYVDLYLMHFPYAYTKGENYSTVRKPDGKPVVDIELSRAFDTTWKAMENLVDQGKAKLIGVSNFSTPKLKRLLSVCRIFPVVNQVELNPYFPQKQLLRFCHEHEIHVTAYGPLGCTPVPYLIGRKTPGPLEDCTVKAMAERYSRTPAQIILAHLIMLGVSVIPKSNNLSRISENFDCLVELSPEDHAALGQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length331
- Mass (Da)36,739
- Last updated2015-05-27 v2
- ChecksumE8264A50B3E363E1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG704913 EMBL· GenBank· DDBJ | EAS30116.3 EMBL· GenBank· DDBJ | Genomic DNA |