J3JZ20 · J3JZ20_DENPD
- Proteinenoyl-CoA hydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids761 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the backward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 149 | Important for long-chain enoyl-CoA hydratase activity | ||||
Sequence: E | ||||||
Site | 171 | Important for long-chain enoyl-CoA hydratase activity | ||||
Sequence: E | ||||||
Site | 496 | Important for hydroxyacyl-coenzyme A dehydrogenase activity | ||||
Sequence: H | ||||||
Active site | 508 | For hydroxyacyl-coenzyme A dehydrogenase activity | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial fatty acid beta-oxidation multienzyme complex | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameenoyl-CoA hydratase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Dendroctonus
Accessions
- Primary accessionJ3JZ20
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 361-539 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: TVAVLGAGLMGAGIAHVTVDKGYDVILKDTNSNGLARGVNQISTGINNAVKRKRISSLDKDRYLANLNATLNYDSFKNADVVIEAVFEDLSIKHKVLKEVEAVVRPECVFATNTSAIPIRNIAAASSRPDKVIGMHYFSPVDKMQLLEIITTDKTSKETTALAVDVGLKQGKVVITVGD | ||||||
Domain | 542-637 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFYTTRILSAMMAESIRLLQEGVDPKDLDSLTKKFGFPVGAATLADEVGLDVASHIGPDLLKAFGERFAGGDQNILSEVVKAGFLGRKSGKGIFVY |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length761
- Mass (Da)81,913
- Last updated2012-10-03 v1
- ChecksumD3A1FF59AB5A7EB5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BT128501 EMBL· GenBank· DDBJ | AEE63458.1 EMBL· GenBank· DDBJ | mRNA |