J3JUE9 · J3JUE9_DENPD

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, active site.

134550100150200250300
TypeIDPosition(s)Description
Binding site26-27NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site78NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site129-131NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site180-181NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site181K+ (UniProtKB | ChEBI)
Binding site183K+ (UniProtKB | ChEBI)
Active site186Thioimidate intermediate
Binding site186K+ (UniProtKB | ChEBI)
Active site188Proton donor/acceptor
Binding site189K+ (UniProtKB | ChEBI)
Binding site219-221GMP (UniProtKB | ChEBI)
Binding site242-243GMP (UniProtKB | ChEBI)
Binding site268-270GMP (UniProtKB | ChEBI)
Binding site269NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site285-286NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site314-317NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits

GO annotations

AspectTerm
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Molecular Functionmetal ion binding
Biological Processpurine nucleobase metabolic process
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Short names
    GMPR
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • Name
      109536346
    • ORF names
      YQE_05431

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Dendroctonus

Accessions

  • Primary accession
    J3JUE9

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-339IMP dehydrogenase/GMP reductase

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    345
  • Mass (Da)
    37,257
  • Last updated
    2012-10-03 v1
  • Checksum
    F0BFC586BE166C8B
MPNIINEIKLDFKDVLLRPKRSTLRSRSDVNLHRHITFRNSKQDYNGIPVMASNMDTVGTFEMAKALSKHGLFTCIHKYYSAEDWKLFASDNPDVISNVAASSGIAQNDYSRLVEILAAVPAIKFVCLDVANGYTQFFVDYVRKVRAAFPTHTIIAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRMKTGVGYPQLSAVIECADAAHGLQGHIIADGGCTCPGDVAKAFGAGADFVMAGGMFAGHDQCGGEVIEKNGKKFKLFYGMSSCTAMKKYAGGVAEYRSSEGKTVEIPYKGDVEETTLDILGGLRSACTYTGAAKLKELPRRATFVRCTQQVNNIYS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
APGK01035338
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
APGK01035339
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BT126862
EMBL· GenBank· DDBJ
AEE61824.1
EMBL· GenBank· DDBJ
mRNA
KB740923
EMBL· GenBank· DDBJ
ENN78280.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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