J2TJR3 · J2TJR3_9PSED

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    cobB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site105-108NAD+ (UniProtKB | ChEBI)
Active site123Proton acceptor
Binding site131Zn2+ (UniProtKB | ChEBI)
Binding site134Zn2+ (UniProtKB | ChEBI)
Binding site182Zn2+ (UniProtKB | ChEBI)
Binding site185Zn2+ (UniProtKB | ChEBI)
Binding site223-225NAD+ (UniProtKB | ChEBI)
Binding site249-251NAD+ (UniProtKB | ChEBI)
Binding site267NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      PMI34_05628

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GM74
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    J2TJR3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-280Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class II subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    280
  • Mass (Da)
    31,027
  • Last updated
    2012-10-03 v1
  • Checksum
    9F9131E3B6D4C283
MLDRQTRDQLDRLHQLMADQPFAVLTGAGISTPSGIPDYRDNQGVRRGRQPMMYQEFLSAPEPRRRYWARAMLGWPRVRLAQPNVAHDTLARLQGTRQISGLITQNVDTLHDQAGSRDVIELHGSLHRVLCLDCGRRSERDSIQRLMETQNPYLAGVDAVQAPDGDTLLDPAFEARFKVPRCPHCAGERMKPDVVFFGENVAQATAAKAMAAVEQAAGLLVVGSSLMAYSAFRLCRAVVDQGKPLIAINLGKTRADEMLDLKIEGSCERLLPLLAERLSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AKJG01000175
EMBL· GenBank· DDBJ
EJM79926.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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