J2TJR3 · J2TJR3_9PSED
- ProteinNAD-dependent protein deacetylase
- GenecobB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids280 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity
- N6-acetyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 105-108 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 123 | Proton acceptor | |||
Binding site | 131 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 134 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 182 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 185 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 223-225 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 249-251 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 267 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent protein lysine deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein deacetylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionJ2TJR3
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-280 | Deacetylase sirtuin-type | |||
Sequence similarities
Belongs to the sirtuin family. Class II subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length280
- Mass (Da)31,027
- Last updated2012-10-03 v1
- Checksum9F9131E3B6D4C283
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AKJG01000175 EMBL· GenBank· DDBJ | EJM79926.1 EMBL· GenBank· DDBJ | Genomic DNA |