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I7MGD8 · I7MGD8_TETTS

Function

Catalytic activity

  • Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.
    EC:3.4.24.84 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1800100200300400500600700800
Type
IDPosition(s)Description
Binding site259Zn2+ (UniProtKB | ChEBI); catalytic
Active site260
Binding site263Zn2+ (UniProtKB | ChEBI); catalytic
Binding site337Zn2+ (UniProtKB | ChEBI); catalytic
Active site341Proton donor

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological ProcessCAAX-box protein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ste24 endopeptidase
  • EC number

Gene names

    • ORF names
      TTHERM_00530150

Organism names

  • Taxonomic identifier
  • Strain
    • SB210
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Hymenostomatida > Tetrahymenina > Tetrahymenidae > Tetrahymena

Accessions

  • Primary accession
    I7MGD8

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane119-145Helical
Transmembrane157-175Helical
Transmembrane273-290Helical

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain2-186CAAX prenyl protease 1 N-terminal
Domain190-393Peptidase M48
Region427-456Disordered
Region696-800Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    800
  • Mass (Da)
    93,356
  • Last updated
    2014-04-16 v2
  • MD5 Checksum
    88ED17E3EDDAB73819473F24B3050560
MIQNYKQIKKMPSDVRSLGIDPDQYKRAMQYAFDKLAFQMYVYSVKTGLECIFSLTYVMPLVWNGVTKLFPIIEPTSEFQRGFMFLLIEALKSKFIDVPIALYETFVIEEKYGFNKKTLFLFFNDLVIEAGLSVIIIPTILYGYIYVVDKTESNEWFFFNVEIFIILFMLAYITINPNFIAPAFNKFEELEDGELKQEINELAISINFPLKDILKMDGSRRSEHSNAYFYGLWNNKRIVLFDTLLNQMSQNEIMSVVGHELGHWKHSHSKIKFLIYCLRIIIIFSLFSFFRNSDSIFLSFGFTDKSTFIGTTLFFNLFSPINSVIEIIDLVISRYFEFQADTFACNLGYGYYLMSGLTKIQKEDVSTLNPDPWYAWFKHSHPGLFERLKRIKQTLFQIEKQNGLENQQIQEKIQNFLEEYVSINGRNHQNIDNSNNRHYINSPNNTNNNNSNNRRQLGSQYQGFLREHANSQNQINGFQSRNPIYHALDRNGSNSLNSSMQQFPITQQQNNQNEIDSNSNQIGYQQALNNTLIQNFANPNTNSGFNLNLLFNYEQQQNQQLIQQQLQMQQMQQQLVSDLLNQWTNQQYLLQQQQQQGVNSGLQLNLGSIAQQQQQQQQHQQQNVLRNNQQLSNSSSSYLITNRKVYKHSISNIESLDSRDYSSSVDINHPNKKLYKEDVYLFGSQIPSNDIRKRQVLQQNQSRPQSPPEFQNNNNFNNNIFNNNISNGFHNSPNQQVINSDQNKEHYQNGINYSPTFNGNQKKQGYQKNGTSLDNNKFSQNNNRSSKINQYQVMNGNGNQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG662522
EMBL· GenBank· DDBJ
EAR85063.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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