I7ISX4 · I7ISX4_BABMR

Function

function

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site491ATP (UniProtKB | ChEBI)
Binding site650-652acetyl-CoA (UniProtKB | ChEBI)
Binding site657-663acetyl-CoA (UniProtKB | ChEBI)
Binding site730acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctiontRNA N-acetyltransferase activity
Biological ProcessrRNA acetylation involved in maturation of SSU-rRNA
Biological ProcesstRNA acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA cytidine acetyltransferase
  • EC number
  • Alternative names
    • 18S rRNA cytosine acetyltransferase

Gene names

    • ORF names
      BmR1_04g08795

Organism names

  • Taxonomic identifier
  • Strain
    • RI
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    I7ISX4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-203tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Domain303-509Helicase
Domain551-757N-acetyltransferase
Domain769-931Possible tRNA binding

Sequence similarities

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    934
  • Mass (Da)
    104,463
  • Last updated
    2012-10-03 v1
  • Checksum
    6AB610E0369C2737
MGARTKKVDSLVRQLIEKCVKLNQRSLLFIIGDKSRLQVSNLHYLLSKVTNSSKPTVLWCYKKKLEVSSNRSKRLKIAKKLAKKASYDAEIEDPFELFLSTTDIRYCLYKDTKQILGQTFNMLVLQDFEALTPNIMCRTIETVKGGGIILFLLDTISSLESLYSITMDAHHKYSTARFNTCQSRFIKRMILSLVTNSNALVVDDELNILPIVNSTPNSSTLDVDNNNGTINVNARNANDSNIGEFDSLNISNYANYDDDDDDNRYSGAKRLHSITVTKDQGQIFYRLLNMLVNKRGTEHYVAITAGRGRGKSAVLGLSIAAALSLGFSNIYVAAPVADNVATLFEFVVKGLETLGFKPHTDFIIYSLDKQEIVPIETNNLTRLFTGSRAKTTKVTTQIVFKGEIKQAITYLSPSDLNNWNSTLTSVELLVIDEAAAMPIHILRKCRGSFITFLSSTINGYEGTGRVLSLRLFNELESKHGLSKLEMMEPIRYAANDPTENWLTKLLCLNATAPPKLGDEISAPNKCELFQVDRDALMSFHPCAEAFLHILKSTFISSHYKNSPDDFILMSDSPSHAVFVLISPADRMNSGVPNVICAIQISLEGRLTKDEISQNINNSKMPAGDLIPWTLTQYYTNEDFGALSGVRIVRIAVHPHLQRMGYGTQAIKLLINFISSSVNNNDDKPYKTFRSNDDVVTPLLVPCDEATFGINVDYIGASFGLTCGLIKFWNNLDFYPVYLKQTPNEIIGEHSCIVIRPITSSLISQSKPTWLSGFAMDFSKRLLALLPGPFSRLPLYSLTYLLFNNTASDNVDNTNDVHVNITQFVNNNLPLSLGYNDLDRLDRYSKQFSQLRSVLDILPFIALLVFTGKIRIELSILQKVVLLGIACQMKQADEIAAELDLPSNQILSILHRTIFNINALIRDGLTKQLERETVN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN871599
EMBL· GenBank· DDBJ
CCF75936.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp