I6LPM8 · I6LPM8_SPIER

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      cox3

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    I6LPM8

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-40Helical
Transmembrane52-74Helical
Transmembrane86-110Helical
Transmembrane116-137Helical
Transmembrane149-177Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-180Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    180
  • Mass (Da)
    20,567
  • Last updated
    2012-10-03 v1
  • Checksum
    489773EF8EF4BAD5
LPIFNSFLFGLVLVGCFLWKLNYLLFVLPLVGFSLLFFWFDLLNWDFHYESAFWLFILSEVIAFGSLLVCCFWFDNNSFISLSSSLEIPFLGCFLLLGSSISITGFHHIMPWSFSWILLLLTIVLGMGFVLLQLFEFNEVFINLTDSSFYASCFCTVGLHFIHVFLGVIGLSIILFLGVA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue180

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM475011
EMBL· GenBank· DDBJ
ADZ36702.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475012
EMBL· GenBank· DDBJ
ADZ36703.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475013
EMBL· GenBank· DDBJ
ADZ36704.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475014
EMBL· GenBank· DDBJ
ADZ36705.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475016
EMBL· GenBank· DDBJ
ADZ36707.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475017
EMBL· GenBank· DDBJ
ADZ36708.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475018
EMBL· GenBank· DDBJ
ADZ36709.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475020
EMBL· GenBank· DDBJ
ADZ36711.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475021
EMBL· GenBank· DDBJ
ADZ36712.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475022
EMBL· GenBank· DDBJ
ADZ36713.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475024
EMBL· GenBank· DDBJ
ADZ36715.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475027
EMBL· GenBank· DDBJ
ADZ36718.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475028
EMBL· GenBank· DDBJ
ADZ36719.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475030
EMBL· GenBank· DDBJ
ADZ36721.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475031
EMBL· GenBank· DDBJ
ADZ36722.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475032
EMBL· GenBank· DDBJ
ADZ36723.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475033
EMBL· GenBank· DDBJ
ADZ36724.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475034
EMBL· GenBank· DDBJ
ADZ36725.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475036
EMBL· GenBank· DDBJ
ADZ36727.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475039
EMBL· GenBank· DDBJ
ADZ36730.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475040
EMBL· GenBank· DDBJ
ADZ36731.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475041
EMBL· GenBank· DDBJ
ADZ36732.1
EMBL· GenBank· DDBJ
Genomic DNA
HM475042
EMBL· GenBank· DDBJ
ADZ36733.1
EMBL· GenBank· DDBJ
Genomic DNA
KM031786
EMBL· GenBank· DDBJ
AIS21523.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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