I3ZRV3 · I3ZRV3_THECF

Function

function

Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

S-adenosyl-L-methionine (UniProtKB | Rhea| CHEBI:59789 )

Note: Binds 1 S-adenosyl-L-methionine per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-14substrate
Binding site32substrate
Binding site36[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site40[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site42-44S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site43[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site45Mg2+ (UniProtKB | ChEBI)
Binding site98substrate
Binding site100S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionmagnesium ion binding
Molecular FunctionS-adenosyl-L-methionine binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-carboxy-7-deazaguanine synthase
  • EC number
  • Short names
    CDG synthase
  • Alternative names
    • Archaeosine biosynthesis protein QueE

Gene names

    • Name
      queE
    • ORF names
      CL1_0225

Organism names

Accessions

  • Primary accession
    I3ZRV3

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-253Radical SAM core

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    28,690
  • Last updated
    2012-09-05 v1
  • Checksum
    D37465B1D3E68D7A
MKLIMAEVFNSWQGEGGSVEGSAFGRRQIFVRFAGCDLDCLWCDSREYINASRVFRWRSEVEPFTGKFEYRPNPASLDEVVEAILRLDTGDIHSISYTGGEPTLQVKPLKALMEEMRSLGFDNFLETHGGLPELIKEVADLTDYASVDIKDETARATEDWRSLVLREVESIRILKEAGAKVYAKLVVTSETKPGNVRWYAELLKGLAPLVIQPREPIEINQEKLMNLYREAALVMGRKNVGLSFQVHKYLNVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003651
EMBL· GenBank· DDBJ
AFL94437.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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