I3ZRD2 · I3ZRD2_THECF
- ProteintRNA-guanine(15) transglycosylase
- GenetgtA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids579 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Catalytic activity
- guanosine15 in tRNA + 7-cyano-7-deazaguanine = 7-cyano-7-carbaguanosine15 in tRNA + guanine
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
tRNA modification; archaeosine-tRNA biosynthesis.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pentosyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | queuosine biosynthetic process | |
Biological Process | tRNA wobble guanine modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-guanine(15) transglycosylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus
Accessions
- Primary accessionI3ZRD2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 505-579 | PUA | ||||
Sequence: MRVVVNSDAEPFARRGKNVFAKFVVDADPSIRPYDEVLVVNEKDELLATGQTLLNGEELKVFGSGLAVKVRRGVG |
Sequence similarities
Belongs to the archaeosine tRNA-ribosyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length579
- Mass (Da)65,685
- Last updated2012-09-05 v1
- ChecksumA8B5576407FFB14A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003651 EMBL· GenBank· DDBJ | AFL94266.1 EMBL· GenBank· DDBJ | Genomic DNA |