I3ZRD2 · I3ZRD2_THECF

Function

function

Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

tRNA modification; archaeosine-tRNA biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site91Nucleophile
Binding site126substrate
Binding site192substrate
Binding site275Zn2+ (UniProtKB | ChEBI)
Binding site277Zn2+ (UniProtKB | ChEBI)
Binding site280Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpentosyltransferase activity
Molecular FunctionRNA binding
Molecular Functionzinc ion binding
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA wobble guanine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-guanine(15) transglycosylase
  • EC number
  • Alternative names
    • 7-cyano-7-deazaguanine tRNA-ribosyltransferase
    • Archaeal tRNA-guanine transglycosylase

Gene names

    • Name
      tgtA
    • ORF names
      CL1_0051

Organism names

Accessions

  • Primary accession
    I3ZRD2

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain505-579PUA

Sequence similarities

Belongs to the archaeosine tRNA-ribosyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    579
  • Mass (Da)
    65,685
  • Last updated
    2012-09-05 v1
  • Checksum
    A8B5576407FFB14A
MVEFKFEVKARDAAGRIGKLTVNGKTVETPAIMPVINPKQLIVTPKELKEMGFGMIITNSYIIYKTPELREKALEVGIHRLLDYDGIIEVDSGSFQLMRYGEVEVTNREIIEFQERIGVDIGTFLDIPTPPDAPREKAKEDLRITLERAKEAEEVKNIAMNAAVQGSTYPDLRTYAAKKLSEMNFEIHPVGAVVPLMESYRYRDLVDVVIASKLGLRPDRPVHLFGAGHPMIFALAVAMGVDLFDSASYALYAKDDRYLTPEGTKRLDELEYFPCSCPVCSRYTPQELREMPKEERTRLLALHNLWVIREELNRVKQAIKEGTLWELVDERARSHPKMFAAYKRLLEYRDYLEKNEPVTKASAFFKVSEEAMGWPIVQRAKERAERVARKFPEKVSHPIFGEIPRYLSLSYPFAQSEGEEDFTIEKPRKSEARKYVMAIAEYQFGEGAGEAFKDAFVELSRKTGMPRQIKAKGKHLATFRAEDGLLTLGIEGAKRLHEVLPFPRMRVVVNSDAEPFARRGKNVFAKFVVDADPSIRPYDEVLVVNEKDELLATGQTLLNGEELKVFGSGLAVKVRRGVG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003651
EMBL· GenBank· DDBJ
AFL94266.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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