I3WSD9 · I3WSD9_NOTSA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids200 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Cirripedia > Thoracica > Thoracicalcarea > Balanomorpha > Chthamaloidea > Chthamalidae > Notochthamalus
Accessions
- Primary accessionI3WSD9
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-46 | Helical | |||
Transmembrane | 67-91 | Helical | |||
Transmembrane | 111-134 | Helical | |||
Transmembrane | 146-173 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length200
- Mass (Da)21,676
- Last updated2012-09-05 v1
- Checksum01AF5BB89383E6DF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 200 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JQ950758 EMBL· GenBank· DDBJ | AFL45799.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950760 EMBL· GenBank· DDBJ | AFL45801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950762 EMBL· GenBank· DDBJ | AFL45803.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950770 EMBL· GenBank· DDBJ | AFL45811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950772 EMBL· GenBank· DDBJ | AFL45813.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950795 EMBL· GenBank· DDBJ | AFL45836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950796 EMBL· GenBank· DDBJ | AFL45837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950799 EMBL· GenBank· DDBJ | AFL45840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950800 EMBL· GenBank· DDBJ | AFL45841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950801 EMBL· GenBank· DDBJ | AFL45842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950802 EMBL· GenBank· DDBJ | AFL45843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950803 EMBL· GenBank· DDBJ | AFL45844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950809 EMBL· GenBank· DDBJ | AFL45850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950811 EMBL· GenBank· DDBJ | AFL45852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950812 EMBL· GenBank· DDBJ | AFL45853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950815 EMBL· GenBank· DDBJ | AFL45856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950816 EMBL· GenBank· DDBJ | AFL45857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950819 EMBL· GenBank· DDBJ | AFL45860.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950820 EMBL· GenBank· DDBJ | AFL45861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950821 EMBL· GenBank· DDBJ | AFL45862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950822 EMBL· GenBank· DDBJ | AFL45863.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950823 EMBL· GenBank· DDBJ | AFL45864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950826 EMBL· GenBank· DDBJ | AFL45867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950827 EMBL· GenBank· DDBJ | AFL45868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950828 EMBL· GenBank· DDBJ | AFL45869.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950829 EMBL· GenBank· DDBJ | AFL45870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950830 EMBL· GenBank· DDBJ | AFL45871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950832 EMBL· GenBank· DDBJ | AFL45873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950833 EMBL· GenBank· DDBJ | AFL45874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950834 EMBL· GenBank· DDBJ | AFL45875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950835 EMBL· GenBank· DDBJ | AFL45876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950836 EMBL· GenBank· DDBJ | AFL45877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950837 EMBL· GenBank· DDBJ | AFL45878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950839 EMBL· GenBank· DDBJ | AFL45880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950842 EMBL· GenBank· DDBJ | AFL45883.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950843 EMBL· GenBank· DDBJ | AFL45884.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950846 EMBL· GenBank· DDBJ | AFL45887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950847 EMBL· GenBank· DDBJ | AFL45888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950848 EMBL· GenBank· DDBJ | AFL45889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950849 EMBL· GenBank· DDBJ | AFL45890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950851 EMBL· GenBank· DDBJ | AFL45892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950852 EMBL· GenBank· DDBJ | AFL45893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950853 EMBL· GenBank· DDBJ | AFL45894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950854 EMBL· GenBank· DDBJ | AFL45895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950855 EMBL· GenBank· DDBJ | AFL45896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950857 EMBL· GenBank· DDBJ | AFL45898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950863 EMBL· GenBank· DDBJ | AFL45904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ950864 EMBL· GenBank· DDBJ | AFL45905.1 EMBL· GenBank· DDBJ | Genomic DNA |