I3WSD9 · I3WSD9_NOTSA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • GuanHX13
    • GuanHX23
    • GuanLX10
    • GuanLX31
    • GuanLX35
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Cirripedia > Thoracica > Thoracicalcarea > Balanomorpha > Chthamaloidea > Chthamalidae > Notochthamalus

Accessions

  • Primary accession
    I3WSD9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-46Helical
Transmembrane67-91Helical
Transmembrane111-134Helical
Transmembrane146-173Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-200Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    200
  • Mass (Da)
    21,676
  • Last updated
    2012-09-05 v1
  • Checksum
    01AF5BB89383E6DF
RAELGQPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLLPLMLGAPDMAFPRLNNMSFWLLPPALMLLISGSLVEAGAGTGWTVYPPLASNIAHSGASVDLSIFSLHLAGASSILGAINFMSTVINMRAETLTFDRLPLFVWSVFVTVILLLLSLPVLAGAITMLLTDRNLNTSFFDPTGGGDPILYQHLFWF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue200

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ950758
EMBL· GenBank· DDBJ
AFL45799.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950760
EMBL· GenBank· DDBJ
AFL45801.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950762
EMBL· GenBank· DDBJ
AFL45803.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950770
EMBL· GenBank· DDBJ
AFL45811.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950772
EMBL· GenBank· DDBJ
AFL45813.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950795
EMBL· GenBank· DDBJ
AFL45836.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950796
EMBL· GenBank· DDBJ
AFL45837.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950799
EMBL· GenBank· DDBJ
AFL45840.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950800
EMBL· GenBank· DDBJ
AFL45841.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950801
EMBL· GenBank· DDBJ
AFL45842.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950802
EMBL· GenBank· DDBJ
AFL45843.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950803
EMBL· GenBank· DDBJ
AFL45844.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950809
EMBL· GenBank· DDBJ
AFL45850.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950811
EMBL· GenBank· DDBJ
AFL45852.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950812
EMBL· GenBank· DDBJ
AFL45853.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950815
EMBL· GenBank· DDBJ
AFL45856.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950816
EMBL· GenBank· DDBJ
AFL45857.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950819
EMBL· GenBank· DDBJ
AFL45860.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950820
EMBL· GenBank· DDBJ
AFL45861.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950821
EMBL· GenBank· DDBJ
AFL45862.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950822
EMBL· GenBank· DDBJ
AFL45863.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950823
EMBL· GenBank· DDBJ
AFL45864.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950826
EMBL· GenBank· DDBJ
AFL45867.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950827
EMBL· GenBank· DDBJ
AFL45868.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950828
EMBL· GenBank· DDBJ
AFL45869.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950829
EMBL· GenBank· DDBJ
AFL45870.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950830
EMBL· GenBank· DDBJ
AFL45871.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950832
EMBL· GenBank· DDBJ
AFL45873.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950833
EMBL· GenBank· DDBJ
AFL45874.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950834
EMBL· GenBank· DDBJ
AFL45875.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950835
EMBL· GenBank· DDBJ
AFL45876.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950836
EMBL· GenBank· DDBJ
AFL45877.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950837
EMBL· GenBank· DDBJ
AFL45878.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950839
EMBL· GenBank· DDBJ
AFL45880.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950842
EMBL· GenBank· DDBJ
AFL45883.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950843
EMBL· GenBank· DDBJ
AFL45884.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950846
EMBL· GenBank· DDBJ
AFL45887.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950847
EMBL· GenBank· DDBJ
AFL45888.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950848
EMBL· GenBank· DDBJ
AFL45889.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950849
EMBL· GenBank· DDBJ
AFL45890.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950851
EMBL· GenBank· DDBJ
AFL45892.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950852
EMBL· GenBank· DDBJ
AFL45893.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950853
EMBL· GenBank· DDBJ
AFL45894.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950854
EMBL· GenBank· DDBJ
AFL45895.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950855
EMBL· GenBank· DDBJ
AFL45896.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950857
EMBL· GenBank· DDBJ
AFL45898.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950863
EMBL· GenBank· DDBJ
AFL45904.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ950864
EMBL· GenBank· DDBJ
AFL45905.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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