I3QJ26 · I3QJ26_PRRSV

Function

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum
Cellular Componenthost cell membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA helicase activity
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral protein processing
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Non-structural protein

Organism names

Accessions

  • Primary accession
    I3QJ26

Proteomes

Subcellular Location

Host cytoplasm
Host endoplasmic reticulum
Host membrane
; Multi-pass membrane protein
Host nucleus

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1228-1256Helical
Transmembrane1263-1279Helical
Transmembrane1341-1359Helical
Transmembrane1618-1642Helical
Transmembrane1654-1682Helical
Transmembrane1688-1717Helical
Transmembrane1991-2017Helical
Transmembrane2029-2050Helical
Transmembrane2062-2082Helical
Transmembrane2102-2127Helical
Transmembrane2134-2152Helical

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain69-180Peptidase C31
Domain263-383Peptidase C32
Region402-422Disordered
Compositional bias407-422Basic and acidic residues
Domain428-535Peptidase C33
Region809-850Disordered
Compositional bias825-841Basic and acidic residues
Region1122-1149Disordered
Domain1780-1983Peptidase S32

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,473
  • Mass (Da)
    268,780
  • Last updated
    2012-09-05 v1
  • Checksum
    D06C59B982148475
MSGILDRCTCTPNARVFVAEGQVYCTRCLSARSLLPLNLQVPELGVLGLFYRPEEPLRWTLPRAFPTVECSPAGACWLSAIFPIARMTSGNLNFQQRMVRVAAEIYRAGQLTPTVLKTLQVYERGCRWYPIVGPVPGVGVYANSLHVSDKPFPGATHVLTNLPLPQRPKPEDFCPFECAMADVYDIGRGAVMYVAGGKVSWAPRGGNEVKFEPVPKELRLVANRLHTSFPPHHVVDMSRFTFMTPGSGVSMRVEYQCGCLPADTVPEGNCWWRLFDSLPPEVQYKEIRHANQFGYQTKHGAPGKYLQRRLQVNGLRAVTDTHGPIVTQYFSVKESWIRHLKLVEEPSLPGFEDLLRIRVEPNTSPLVGKDEKIFRFGSHKWYGAGKRARKTRSGATTVVAHHASSAHETRQATKHEGAGANKAEHLKRYSPPAEGNCGWHCISAIANRMVNSNFETTLPERARPSDDWATDEDLVNTIQILRLPAALDRNGACGSAKYVLKLEGEHWTVSVTPGMSPTLLPLECVQGCCEHKGGLVSPDAVEISGFDPACLDRLAKVMHLPSSAIPAALAELSDDSNRPVSPAATTWTVSQFYARHGGGDHHDQVCLGKIISLCQVIEDCCCHQNKTNRATPEEVAAKIDQYLRGATSLEECLAKLERVSPPGAADTSFDWNVVLPGVEAVNQTTEQPHVNSCCTLVPPVTQEPLGKDSVPLTAFSLSNCYYPAQGDEVHHRERLNSVLSKLEEVVLEEYGLMSTGLGPRPVFPIGLDELKDQMEEDLLKLANTQATSEMMARAAEQVDLKAWVKSYPRWAPPPPPPRVQPRRTKSVKSLPENKPVPAPRRKARSDCGGPVLMGDNVPNGSEETVGGPLNFPTPSELMTPMSEPVLAPASQFVPKLMTPLIGSAPVPAPRRTVTTTLTHQDEPLDLSASSQTEYKAFPLAPSQNMGILEAGGQEAEEVLSEISDILNDTNPAPVSSSSSLSSVKITRPKYSAQAIIDSGGPCSGHLQKEKEACLSIMREACDASKLSDPATQEWLSHMWDRVDMLTWRNTSAYQAFRILNGRFGFLPKMILETPPPYPCGFVMLPHTPAPSVSAESDLTIGSVATEDVPRILGKIGDTNELLDRGPLAPSKGEPVCDQPAKDPLMSPRESDESIIAPPADTGGVGSFTDLPSSDGVDVDGGGLLRTVKTKAGRFIDQLSCQVFSLVSHLPIFFSHLFKSDSGYSPGDWGFAAFTLFCLFLCYSYPFFGFAPLLGVFSGSSRRVRMGVFGCWLAFAVGLFKPVSDPVGNACEFDSPECRNVLHSFELLKPWDPVRSLVVGPVGLGLAILGRLLGGARYIWHFLLRLGIVADCILAGAYVLSQGRCKRCWGSCVRTAPNEIAFNVFPFTRATRSSLIDLCDRFCAPKGMDPIFLATGWRGCWTGRSPIEQPSEKPIAFAQLDEKRITARTVVAQPYDPNQAVKCLRVLQAGGAMVAEAVPKVVKVSAIPFRAPFFPAGVKVDPECRIVVDPDTFTTALRSGYSTANLVLGTGDFAQLNGLKIRQISKPSGGGPHLIAALHVACSMALHMLAGVYITAVGSCGTGTNDPWCTNPFAVPGYGPGSLCTSRLCISQHGLTLPLTALVVGFGLQEIALVVLIFVSVGGMAHRLSCKADMLCILLAIASYVWVPLTWLLCVFPCWLRWFSLHPLTILWLVFFLISVNIPSGILAVVLLVSLWLLGRYTNIAGLVTPYDIHHYTSGPRGVAALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSLLEGAFRTQKPSLNTVNVVGSSMGSGGVFTIDGKIKCVTAAHVLTGNSARVSGVGFNQMLDFDVKGDFAIADCPNWQGVAPKAQFCEDGWTGRAYWLTSSGVEPGVIGNGFAFCFTACGDSGSPVITEAGELVGVHTGSNKQGGGIVTRPSGQFCNVKPIKLSELSEFFAGPKVPLGDVKIGSHIIKDICEVPSDLCALLAAKPELEGGLSTVQLLCVFFLLWRMMGHAWTPLVAVGFFILNEILPAVLVRSVFSFGMFVLSWLTPWSAQVLMIRLLTAALNRNRWSLGFYSLGAVTSFVADLAVTQGHPLQVVMNLSTYAFLPRVMVMTSPVPVIACGVVHLLAIILYLFKYRCLHNVLVGDGVFSSAFFLRYFAEGKLREGVSQSCGMSHESLTGALAMRLTDEDLDFLTKWTDFKCFVSASNMRNAAGQFIEAAYAKALRIELAQLVQVDKVRGTMAKLEAFADTVAPQLSPGDIVVALGHTPVGSIFDLKVGSTKHTLQAIETRVLAGSKMTVARVVDPTPAPPPVPVPIPLPPKVLENGPNAWGDEDRLNKKKRRRMEAVGIFVMDGKKYQKFWDKNSGDVFYEEVHVSTDEWECLRTGDPVDFDPETGIQCGHITIEDKVYNVFTSPSGRRFLVPANPENRRAQWEAAKLSVEQALGMMNVDGELTAKELEKLKRIIDKLQGLTKEQCLNC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias407-422Basic and acidic residues
Compositional bias825-841Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ663562
EMBL· GenBank· DDBJ
AFK09163.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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