The mammalian PYHIN gene family: phylogeny, evolution and expression.Cridland J.A., Curley E.Z., Wykes M.N., Schroder K., Sweet M.J., Roberts T.L., Ragan M.A., Kassahn K.S., Stacey K.J.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6TissueSpleenCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCBMC Evol Biol 12:140-140 (2012)Cited in1Mapped to23
Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against <i>Clostridium perfringens</i> Infection.Ma Z., Lou Y., Wang N., Zhao Y., Zhang S., Zhang M., Li J., Xu Q., He A., Yu S.View abstractSourceMGI: 2686159PubMedEurope PMCInt J Mol Sci 25:6571-6571 (2024)Mapped to4
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoriesFunctionSourceMGI: 2686159PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice.Yang S., Guo R., Meng X., Zhang Y.View abstractAnnotationAIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice.CategoriesFunctionSourceGeneRif: 383619PubMedEurope PMCJ Asthma 61:479-490 (2024)Mapped to4
TLR9-independent CD8pisup>+pi/sup> T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.Kumar S.R.P., Biswas M., Cao D., Arisa S., Munoz-Melero M., Lam A.K., Pineros A.R., Kapur R., Kaisho T.[...], Herzog R.W.View abstractSourceMGI: 2686159PubMedEurope PMCMol Ther 32:325-339 (2024)Mapped to57
AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3.Ye H., Yu W., Li Y., Bao X., Ni Y., Chen X., Sun Y., Chen A., Zhou W., Li J.View abstractAnnotationAIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3.CategoriesSequencesSourceGeneRif: 383619PubMedEurope PMCHum Vaccin Immunother 19:2269790-2269790 (2023)Mapped to2
AIM2 promotes Tpisub>Hpi/sub>17 cells differentiation by regulating RORgammat transcription activity.Leite J.A., Menezes L., Martins E., Rodrigues T.S., Tavares L., Ebering A., Schelmbauer C., Martelossi Cebinelli G.C., Zinina V.[...], Saraiva Camara N.O.View abstractCategoriesSubcellular LocationSourceMGI: 2686159PubMedEurope PMCiScience 26:108134-108134 (2023)Mapped to8
TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.Yu T., Yang X., Fu Q., Liang J., Wu X., Sheng J., Chen Y., Xiao L., Wu Y.[...], Hu S.View abstractAnnotationTRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.CategoriesNamesSourceGeneRif: 383619PubMedEurope PMCCell Rep 42:113231-113231 (2023)Mapped to10
Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12- PANoptosome activation and inflammatory cell death (PANoptosis).Sharma B.R., Karki R., Rajesh Y., Kanneganti T.D.View abstractAnnotationImmune regulator IRF1 contributes to ZBP1- AIM2- RIPK1- and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).CategoriesNamesSourceGeneRif: 383619PubMedEurope PMCJ Biol Chem 299:105141-105141 (2023)Mapped to14
Macrophage IL-1beta contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment.Chew Z.H., Cui J., Sachaphibulkij K., Tan I., Kar S., Koh K.K., Singh K., Lim H.M., Lee S.C.[...], Lim L.H.K.View abstractCategoriesFunctionSourceMGI: 2686159PubMedEurope PMCFront Immunol 14:1211730-1211730 (2023)Mapped to4
Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis.Ye L., Shu S., Jia J., Sun M., Xu S., Bao X., Bian H., Liu Y., Zhang M.[...], Xu Y.View abstractAnnotationAbsent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis.CategoriesFunctionSourceGeneRif: 383619PubMedEurope PMCAging Cell 22:e13860-e13860 (2023)Mapped to2
The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome.Dawson R.E., Deswaerte V., West A.C., Sun E., Wray-McCann G., Livis T., Kumar B., Rodriguez E., Gabay C.[...], Jenkins B.J.View abstractAnnotationThe cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome.CategoriesFunction, ExpressionSourceGeneRif: 383619PubMedEurope PMCImmunol Cell Biol 101:444-457 (2023)Mapped to4
Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model.Chen Y., Pu J., Li X., Lian L., Ge C., Liu Z., Wang W., Hou L., Chen W., Li J.View abstractAnnotationAim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model.CategoriesFunctionSourceGeneRif: 383619PubMedEurope PMCInvest Ophthalmol Vis Sci 64:26-26 (2023)Mapped to2
Microglial AIM2 alleviates antiviral-related neuro-inflammation in mouse models of Parkinson's disease.Rui W.J., Li S., Yang L., Liu Y., Fan Y., Hu Y.C., Ma C.M., Wang B.W., Shi J.P.View abstractCategoriesFunctionSourceMGI: 2686159PubMedEurope PMCGlia 70:2409-2425 (2022)Mapped to13
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.Feng S., Enosi Tuipulotu D., Pandey A., Jing W., Shen C., Ngo C., Tessema M.B., Li F.J., Fox D.[...], Man S.M.View abstractCategoriesFunctionSourceMGI: 2686159PubMedEurope PMCNat Commun 13:4395-4395 (2022)Mapped to29
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.Barclay W.E., Aggarwal N., Deerhake M.E., Inoue M., Nonaka T., Nozaki K., Luzum N.A., Miao E.A., Shinohara M.L.View abstractAnnotationThe AIM2 inflammasome is activated in astrocytes during the late phase of EAE.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 383619PubMedEurope PMCJCI Insight 7:e155563-e155563 (2022)Mapped to2
The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease.Wu H., Deng Y., Long D., Yang M., Li Q., Feng Y., Chen Y., Qiu H., Huang X.[...], Lu Q.View abstractAnnotationThe IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease.CategoriesFunction, ExpressionSourceGeneRif: 383619PubMedEurope PMCClin Transl Med 12:e781-e781 (2022)Mapped to4
Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells.Lozano-Ruiz B., Tzoumpa A., Martinez-Cardona C., Moreno D., Aransay A.M., Cortazar A.R., Pico J., Peiro G., Lozano J.[...], Gonzalez-Navajas J.M.View abstractCategoriesFunction, ExpressionSourceMGI: 2686159PubMedEurope PMCInt J Mol Sci 23:2230-2230 (2022)Mapped to6
AIM2 Inflammasome Activation Contributes to Aortic Dissection in a Sporadic Aortic Disease Mouse Model.Ageedi W., Zhang C., Frankel W.C., Dawson A., Li Y., Coselli J.S., Shen H.Y., LeMaire S.A.View abstractAnnotationAIM2 Inflammasome Activation Contributes to Aortic Dissection in a Sporadic Aortic Disease Mouse Model.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 383619PubMedEurope PMCJ Surg Res 272:105-116 (2022)Mapped to4
AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis.Chung H., Komada T., Lau A., Chappellaz M., Platnich J.M., de Koning H.D., Petri B., Luque Y., Walker S.[...], Muruve D.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2686159PubMedEurope PMCJ Immunol 207:2799-2812 (2021)Mapped to6
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.Karki R., Sundaram B., Sharma B.R., Lee S., Malireddi R.K.S., Nguyen L.N., Christgen S., Zheng M., Wang Y.[...], Kanneganti T.D.View abstractCategoriesFunction, InteractionSourceMGI: 2686159PubMedEurope PMCCell Rep 37:109858-109858 (2021)Mapped to42
Nuclear AIM2-Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair.Jiang H., Swacha P., Gekara N.O.View abstractAnnotationNuclear AIM2-Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair.CategoriesFunction, Subcellular LocationSourceGeneRif: 383619PubMedEurope PMCAdv Sci (Weinh) 8:e2102534-e2102534 (2021)Mapped to2
AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusion.Poh L., Razak S.M.B.A., Lim H.M., Lai M.K.P., Chen C.L., Lim L.H.K., Arumugam T.V., Fann D.Y.View abstractAnnotationAIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusion.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 383619, MGI: 2686159PubMedEurope PMCExp Neurol 346:113856-113856 (2021)Mapped to4
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.Lee S., Karki R., Wang Y., Nguyen L.N., Kalathur R.C., Kanneganti T.D.View abstractAnnotationAIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.CategoriesFunction, InteractionSourceGeneRif: 383619PubMedEurope PMCNature 597:415-419 (2021)Cited in9Mapped to16
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.Fukuda K., Okamura K., Riding R.L., Fan X., Afshari K., Haddadi N.S., McCauley S.M., Guney M.H., Luban J.[...], Harris J.E.View abstractAnnotationAIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.CategoriesFunctionSourceGeneRif: 383619PubMedEurope PMCJ Exp Med 218:e20200962-e20200962 (2021)Mapped to4