I3PA93 · I3PA93_CAJCA

Function

Catalytic activity

Cofactor

Ni cation (UniProtKB | Rhea| CHEBI:25516 )

Note: Binds 2 nickel ions per subunit.

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

Features

Showing features for binding site, active site.

1838100200300400500600700800
TypeIDPosition(s)Description
Binding site29Mg2+ (UniProtKB | ChEBI)
Binding site406Ni2+ 1 (UniProtKB | ChEBI)
Binding site408Ni2+ 1 (UniProtKB | ChEBI)
Binding site489Ni2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site489Ni2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site491substrate
Binding site518Ni2+ 2 (UniProtKB | ChEBI)
Binding site544Ni2+ 2 (UniProtKB | ChEBI)
Active site592Proton donor
Binding site632Ni2+ 1 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenturease complex
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease
  • EC number
  • Alternative names
    • Urea amidohydrolase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > indigoferoid/millettioid clade > Phaseoleae > Cajanus

Accessions

  • Primary accession
    I3PA93

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue489N6-carboxylysine

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain401-838Urease

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    90,023
  • Last updated
    2012-09-05 v1
  • Checksum
    C81F600890DB7734
MKLSPREIEKLSLHNAGYLAQKRLARGLRLNYAETVALIATQIVEFVRDGDKTVAQLMSIGRELLGRRQVLPAVPHLVESVQVEATFRDGTELVTIHDPIACENGNLELALFGSFLPVPSLDKFTANDEDNRIPGEIIVVGGNLVLNHGRKAVILKVVNNGDRPVQVGSHYHFIELNPYLTFDRRKAYGMRLNIAAGNASRFEPGESKSVLLVSIGGNKVIRGGNNIADGPVNDSNCIAAMQAVITRGFGHVEEENAREGVTGEDYSLTTVISREEYANKYGPTTGDKIRLGDTNLFAEIEKDFAIYGDECIFGGGKVIRDGMGQSCGHPPEGSLDTVITNAVIIDYSGIIKADIGIKDGLIISIGKSGNPDVMDGVFQPPTTFGANTEVIAGEGLIVTAGAIDCHVHFICPQLVDDAVTSGITTLVGGGTGPAEGTRATTCTPAPIQMKFMLQSTDDMPLNFGFTGKGNCAKPDELHEIIKAGAMGLKLHEDWGTTPAAIDSCLTIAEQYDIQVNIHTDTLNESGFVEHTIAAFKGRTIHTYHSEGAGGGHAPDIIKVCGEKNVLPSSTNPTRPYTSNTIDEHVDMLMVCHHLKRNIPEDVAFSESRIRAETIAAEDILHDMGAISIISSDSQAMGRIGEVISRTWQTADKMKSQRGPLQPGEENDNLRIKRYVAKYTINPAIANGFSQYIGSVEVGKLADLVLWKPSFFGAKPEMVIKGGEVAYANMGDPNASIPTPEPVIMRPMFGAFGKAGSAHSIAFVSKAALDNGVKASYGLNKRVEAVENVRKLTKLDGKLNDALPEITVEPESYAVTADGVVLTCAAATTVPLSRNYFIF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN107804
EMBL· GenBank· DDBJ
AEN84301.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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