I3N450 · I3N450_ICTTR

Function

Catalytic activity

  • 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H+
    This reaction proceeds in the forward direction.

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site49Ca2+ (UniProtKB | ChEBI)
Binding site51Ca2+ (UniProtKB | ChEBI)
Active site67
Binding site68Ca2+ (UniProtKB | ChEBI)
Active site112

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular space
Cellular Componentmitochondrial outer membrane
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Biological Processarachidonic acid secretion
Biological Processdefense response to Gram-positive bacterium
Biological Processkilling of cells of another organism
Biological Processlipid catabolic process
Biological Processphosphatidic acid metabolic process
Biological Processphosphatidylcholine metabolic process
Biological Processphosphatidylethanolamine metabolic process
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processregulation of neutrophil activation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2
  • EC number

Gene names

    • Name
      PLA2G2A

Organism names

Accessions

  • Primary accession
    I3N450

Proteomes

Subcellular Location

Mitochondrion outer membrane
; Peripheral membrane protein
Secreted

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_500139067921-145Phospholipase A2
Disulfide bond46↔138
Disulfide bond48↔64
Disulfide bond63↔118
Disulfide bond69↔145
Disulfide bond70↔111
Disulfide bond79↔104
Disulfide bond97↔109

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-139Phospholipase A2

Sequence similarities

Belongs to the phospholipase A2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    16,316
  • Last updated
    2012-07-11 v1
  • Checksum
    E6E1473E25E95E8F
MRTLLALAVIMVFGLMWVQGDLLNFNSMISSVTKKNGATNYGAYGCHCGLGGKGAPKDATDRCCARHDCCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYCFAKNRKTYNRKYQFYPNVLCRGKKPSC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGTP01007395
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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