I3N450 · I3N450_ICTTR
- ProteinPhospholipase A2
- GenePLA2G2A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids145 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H+This reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular space | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipase A2 activity | |
Molecular Function | phospholipid binding | |
Biological Process | arachidonic acid secretion | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | killing of cells of another organism | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidic acid metabolic process | |
Biological Process | phosphatidylcholine metabolic process | |
Biological Process | phosphatidylethanolamine metabolic process | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | regulation of neutrophil activation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipase A2
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciuromorpha > Sciuridae > Xerinae > Marmotini > Ictidomys
Accessions
- Primary accessionI3N450
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MRTLLALAVIMVFGLMWVQG | ||||||
Chain | PRO_5001390679 | 21-145 | Phospholipase A2 | |||
Sequence: DLLNFNSMISSVTKKNGATNYGAYGCHCGLGGKGAPKDATDRCCARHDCCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYCFAKNRKTYNRKYQFYPNVLCRGKKPSC | ||||||
Disulfide bond | 46↔138 | |||||
Sequence: CHCGLGGKGAPKDATDRCCARHDCCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYCFAKNRKTYNRKYQFYPNVLC | ||||||
Disulfide bond | 48↔64 | |||||
Sequence: CGLGGKGAPKDATDRCC | ||||||
Disulfide bond | 63↔118 | |||||
Sequence: CCARHDCCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYC | ||||||
Disulfide bond | 69↔145 | |||||
Sequence: CCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYCFAKNRKTYNRKYQFYPNVLCRGKKPSC | ||||||
Disulfide bond | 70↔111 | |||||
Sequence: CYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQC | ||||||
Disulfide bond | 79↔104 | |||||
Sequence: CGTKFLSYKFKYQAGKVICEANQSYC | ||||||
Disulfide bond | 97↔109 | |||||
Sequence: CEANQSYCRSQLC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-139 | Phospholipase A2 | ||||
Sequence: DLLNFNSMISSVTKKNGATNYGAYGCHCGLGGKGAPKDATDRCCARHDCCYKRLEKRGCGTKFLSYKFKYQAGKVICEANQSYCRSQLCQCDKTAAYCFAKNRKTYNRKYQFYPNVLCR |
Sequence similarities
Belongs to the phospholipase A2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length145
- Mass (Da)16,316
- Last updated2012-07-11 v1
- ChecksumE6E1473E25E95E8F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGTP01007395 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |