I3MRV6 · I3MRV6_ICTTR

Function

Catalytic activity

  • Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
    EC:3.4.23.5 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

141150100150200250300350400
TypeIDPosition(s)Description
Active site97
Active site294

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome lumen
Cellular Componentendosome membrane
Cellular Componentextracellular space
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Molecular Functionaspartic-type endopeptidase activity
Biological Processautophagosome assembly
Biological Processinsulin catabolic process
Biological Processinsulin receptor recycling
Biological Processlipoprotein catabolic process
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Processproteolysis
Biological Processregulation of establishment of protein localization

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cathepsin D
  • EC number

Gene names

    • Name
      CTSD

Organism names

Accessions

  • Primary accession
    I3MRV6

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_500367725721-411Cathepsin D
Disulfide bond91↔160
Disulfide bond110↔117
Glycosylation134N-linked (GlcNAc...) asparagine
Glycosylation262N-linked (GlcNAc...) asparagine
Disulfide bond285↔289
Disulfide bond328↔365

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-406Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    411
  • Mass (Da)
    44,462
  • Last updated
    2012-07-11 v1
  • Checksum
    73EB38C99548C6F6
MQPPSLLLLALGLLAASASALIRIPLYKFTSIRRTMTEAGGPVEGLVAQGPITKYSLQSSDRTKGPVPEILKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSGKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCNSGPSLAPGGLKIERQIFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMEQKLVDKNVFSFYLNRDPSGQPGGELMLGGIDSKYYKGSLSYLNVTRKAYWQVHMDQIEVANGLTLCKKGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYIIPCEKVASLPKVSLRLGGKDYTLSPESYTLKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGPYYTVFDRDNNRVGFAEATKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGTP01109991
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGTP01109992
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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