I3M3V7 · I3M3V7_ICTTR

Function

Catalytic activity

  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H+
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site21Ca2+ (UniProtKB | ChEBI)
Binding site23Ca2+ (UniProtKB | ChEBI)
Binding site25Ca2+ (UniProtKB | ChEBI)
Active site41
Binding site42Ca2+ (UniProtKB | ChEBI)
Active site92

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular space
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functionsignaling receptor binding
Biological Processantibacterial humoral response
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processarachidonic acid secretion
Biological Processdefense response to Gram-positive bacterium
Biological Processfatty acid biosynthetic process
Biological Processinnate immune response in mucosa
Biological Processlipid catabolic process
Biological Processphosphatidylcholine metabolic process
Biological Processphosphatidylglycerol metabolic process
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of podocyte apoptotic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2
  • EC number

Gene names

    • Name
      PLA2G1B

Organism names

Accessions

  • Primary accession
    I3M3V7

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond22↔38
Disulfide bond37↔98
Disulfide bond44↔91
Disulfide bond54↔84
Disulfide bond77↔89

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-117Phospholipase A2

Sequence similarities

Belongs to the phospholipase A2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    117
  • Mass (Da)
    13,036
  • Last updated
    2017-11-22 v2
  • Checksum
    7F592CDD0DE854C9
VIKCTIPGSDPYKDYNNYGCFCGLGGSGTPVDELDRCCQKHDACYSQAKKLPSCKFLVDNPYTNTYSYTCSGTEVICSSKNKECEAFICNCDREAAICFSKAPYNKEHKNLDTDKFC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGTP01090478
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGTP01090479
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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