I3M3V7 · I3M3V7_ICTTR
- ProteinPhospholipase A2
- GenePLA2G1B
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids117 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+This reaction proceeds in the forward direction.
- 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H+
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+This reaction proceeds in the forward direction.
- N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipase A2 activity | |
Molecular Function | phospholipid binding | |
Molecular Function | signaling receptor binding | |
Biological Process | antibacterial humoral response | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | arachidonic acid secretion | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | innate immune response in mucosa | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylcholine metabolic process | |
Biological Process | phosphatidylglycerol metabolic process | |
Biological Process | positive regulation of fibroblast proliferation | |
Biological Process | positive regulation of podocyte apoptotic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipase A2
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciuromorpha > Sciuridae > Xerinae > Marmotini > Ictidomys
Accessions
- Primary accessionI3M3V7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 22↔38 | |||||
Sequence: CGLGGSGTPVDELDRCC | ||||||
Disulfide bond | 37↔98 | |||||
Sequence: CCQKHDACYSQAKKLPSCKFLVDNPYTNTYSYTCSGTEVICSSKNKECEAFICNCDREAAIC | ||||||
Disulfide bond | 44↔91 | |||||
Sequence: CYSQAKKLPSCKFLVDNPYTNTYSYTCSGTEVICSSKNKECEAFICNC | ||||||
Disulfide bond | 54↔84 | |||||
Sequence: CKFLVDNPYTNTYSYTCSGTEVICSSKNKEC | ||||||
Disulfide bond | 77↔89 | |||||
Sequence: CSSKNKECEAFIC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-117 | Phospholipase A2 | ||||
Sequence: VIKCTIPGSDPYKDYNNYGCFCGLGGSGTPVDELDRCCQKHDACYSQAKKLPSCKFLVDNPYTNTYSYTCSGTEVICSSKNKECEAFICNCDREAAICFSKAPYNKEHKNLDTDKFC |
Sequence similarities
Belongs to the phospholipase A2 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length117
- Mass (Da)13,036
- Last updated2017-11-22 v2
- Checksum7F592CDD0DE854C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGTP01090478 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGTP01090479 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |