I3LG77 · I3LG77_PIG
- ProteinDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
- GeneSAMHD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids627 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H+This reaction proceeds in the forward direction.
- dATP + H2O = 2'-deoxyadenosine + triphosphate + H+This reaction proceeds in the forward direction.
- dCTP + H2O = 2'-deoxycytidine + triphosphate + H+This reaction proceeds in the forward direction.
- dGTP + H2O = 2'-deoxyguanosine + triphosphate + H+This reaction proceeds in the forward direction.
- dTTP + H2O = thymidine + triphosphate + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 116 | dGTP 1 (UniProtKB | ChEBI) | |||
Binding site | 119 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 137 | dGTP 1 (UniProtKB | ChEBI) | |||
Binding site | 142 | dGTP 1 (UniProtKB | ChEBI) | |||
Binding site | 145 | dGTP 1 (UniProtKB | ChEBI) | |||
Binding site | 149 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 150 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 156 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 164 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 210 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 215 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 233 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 312 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 315 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 319 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 330 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 333 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 352 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 354 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 358 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 366 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 372 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 374 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 375 | dGTP 3 (UniProtKB | ChEBI) | |||
Binding site | 376 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 377 | dGTP 2 (UniProtKB | ChEBI) | |||
Binding site | 451 | dGTP 1 (UniProtKB | ChEBI) | |||
Binding site | 524 | dGTP 2 (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionI3LG77
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | |||
Region | 1-41 | Disordered | |||
Domain | 45-110 | SAM | |||
Domain | 164-316 | HD | |||
Sequence similarities
Belongs to the SAMHD1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length627
- Mass (Da)71,968
- Last updated2017-11-22 v2
- ChecksumACF90BFD6766FDAB
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5G2RD15 | A0A5G2RD15_PIG | SAMHD1 | 575 | ||
A0A5G2Q7I5 | A0A5G2Q7I5_PIG | SAMHD1 | 592 | ||
A0A5G2QZ64 | A0A5G2QZ64_PIG | SAMHD1 | 590 | ||
I3LSQ7 | I3LSQ7_PIG | SAMHD1 | 621 | ||
A0A5G2QUS9 | A0A5G2QUS9_PIG | SAMHD1 | 557 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQIR01095001 EMBL· GenBank· DDBJ | HDA50477.1 EMBL· GenBank· DDBJ | Transcribed RNA | ||
DQIR01222192 EMBL· GenBank· DDBJ | HDB77669.1 EMBL· GenBank· DDBJ | Transcribed RNA |