I3II12 · I3II12_9BACT

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site11substrate
Binding site62substrate
Active site71
Active site71Proton donor
Binding site72-73substrate
Binding site164substrate
Site166Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site197substrate
Site215Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site215-216substrate
Active site224Proton acceptor
Binding site225-226substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      KSU1_B0500

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Planctomycetota > Candidatus Brocadiia > Candidatus Brocadiales > Candidatus Brocadiaceae > Candidatus Jettenia

Accessions

  • Primary accession
    I3II12

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    30,811
  • Last updated
    2012-07-11 v1
  • Checksum
    F6BD6FC5340CE5DD
MRFTKMHGIGNDYIYINCFEEEVKEPAKLAPRMSDRHFGIGSDGIILILPSTVADCKMRIFNADGSEAQMCGNGVRCVAKYIYDHNITRNNPLTVETVAGIKSIELFTDNGRVSGAKVNMGKPRLLRSEIPMLGKEIKETSVIDELLTISNGISWRITCVSMGNPHGIIFVDNLDLVNISKHGIEIEHHPVFPERINVHFVQVHNPKEVTMRTWERGSGITLACGTGASAVCVAGVLNKKTERKILAHLPGGDLKLEWAEDGNVYMTGPAAEVFTGEWH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BAFH01000002
EMBL· GenBank· DDBJ
GAB61357.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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