I2A7R4 · I2A7R4_9MYCO
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids508 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- glycerol + ATP = sn-glycerol 3-phosphate + ADP + H+
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 15 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 15 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 16 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 17 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 19 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 85 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 85 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 86 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 86 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 137 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 137 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 252 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 252 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 253 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 274 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 274 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 318 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 318 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 322 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 419 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 419 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 423 | ADP (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol-3-phosphate metabolic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionI2A7R4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-259 | Carbohydrate kinase FGGY N-terminal | ||||
Sequence: AAIDQGTTSTRCMIFDHEGAEVARHQLEHEQILPQAGWVEHDPVEIWERTSSVLTSVLNRANLAPKNIAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALGADGRGEVIRRKAGLPPATYFSGAKLRWILENVDGVRDAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFAIPRAMLPRIGPSSSPQPYGVTAETGPAGGEIAITGVVGDQHAAMVG | ||||||
Domain | 269-458 | Carbohydrate kinase FGGY C-terminal | ||||
Sequence: KNTYGTGNFLLLNTGETIVRSDNGLLTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLA |
Sequence similarities
Belongs to the FGGY kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length508
- Mass (Da)54,922
- Last updated2012-07-11 v1
- Checksum3E7DC1AB4E351D0D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003491 EMBL· GenBank· DDBJ | AFJ33338.1 EMBL· GenBank· DDBJ | Genomic DNA |