I2A7R4 · I2A7R4_9MYCO

Function

function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

Catalytic activity

Activity regulation

Inhibited by fructose 1,6-bisphosphate (FBP).

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site15ADP (UniProtKB | ChEBI)
Binding site15ATP (UniProtKB | ChEBI)
Binding site15sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site16ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Binding site19ADP (UniProtKB | ChEBI)
Binding site85glycerol (UniProtKB | ChEBI)
Binding site85sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site86glycerol (UniProtKB | ChEBI)
Binding site86sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site137glycerol (UniProtKB | ChEBI)
Binding site137sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site252glycerol (UniProtKB | ChEBI)
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253glycerol (UniProtKB | ChEBI)
Binding site274ADP (UniProtKB | ChEBI)
Binding site274ATP (UniProtKB | ChEBI)
Binding site318ADP (UniProtKB | ChEBI)
Binding site318ATP (UniProtKB | ChEBI)
Binding site322ATP (UniProtKB | ChEBI)
Binding site419ADP (UniProtKB | ChEBI)
Binding site419ATP (UniProtKB | ChEBI)
Binding site423ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionglycerol kinase activity
Biological Processglycerol catabolic process
Biological Processglycerol-3-phosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol kinase
  • EC number
  • Alternative names
    • ATP:glycerol 3-phosphotransferase
    • Glycerokinase
      (GK
      )

Gene names

    • Name
      glpK
    • ORF names
      W7S_01765

Organism names

  • Taxonomic identifier
  • Strain
    • MOTT36Y
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    I2A7R4

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-259Carbohydrate kinase FGGY N-terminal
Domain269-458Carbohydrate kinase FGGY C-terminal

Sequence similarities

Belongs to the FGGY kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    508
  • Mass (Da)
    54,922
  • Last updated
    2012-07-11 v1
  • Checksum
    3E7DC1AB4E351D0D
MAEFAEFVAAIDQGTTSTRCMIFDHEGAEVARHQLEHEQILPQAGWVEHDPVEIWERTSSVLTSVLNRANLAPKNIAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALGADGRGEVIRRKAGLPPATYFSGAKLRWILENVDGVRDAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFAIPRAMLPRIGPSSSPQPYGVTAETGPAGGEIAITGVVGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGETIVRSDNGLLTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPADLRANWQEGRRWSPTWNDQQRAEGYAGWRKAVQRTLDWVSIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003491
EMBL· GenBank· DDBJ
AFJ33338.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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