I1SQ10 · I1SQ10_9DIPS
- ProteinNAD(P)H-quinone oxidoreductase
- GenendhJ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids139 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a plastoquinone + (n+1) H+(in) + NADH = a plastoquinol + n H+(out) + NAD+
a plastoquinone RHEA-COMP:9562 + (n+1) H+ (in)CHEBI:15378+ CHEBI:57945 = a plastoquinol RHEA-COMP:9561 + n H+ (out)CHEBI:15378+ CHEBI:57540 - a plastoquinone + (n+1) H+(in) + NADPH = a plastoquinol + n H+(out) + NADP+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast thylakoid membrane | |
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | quinone binding | |
Biological Process | photosynthesis, light reaction |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H-quinone oxidoreductase
Gene names
Encoded on
- Chloroplast
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Dipsacales > Caprifoliaceae > Valeriana
Accessions
- Primary accessionI1SQ10
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Plastid, chloroplast thylakoid membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-133 | NADH:ubiquinone oxidoreductase 30kDa subunit | ||||
Sequence: QIKPEDWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVDQPEEVCIKVFASRRHPRIPSVFWVWKSVDFQERESYDMLGIYYDNHPRLKRILMPESWIGWPLRKDYIA |
Sequence similarities
Belongs to the complex I 30 kDa subunit family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length139
- Mass (Da)16,588
- Last updated2012-07-11 v1
- Checksum7D104180A4ADB204
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: H | ||||||
Non-terminal residue | 139 | |||||
Sequence: I |