I1RY35 · ERG13_GIBZE

Function

function

Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity).
ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (By similarity).
The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable)

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Proton donor/acceptor
Active site118Acyl-thioester intermediate
Active site259Proton donor/acceptor

GO annotations

AspectTerm
Molecular Functionhydroxymethylglutaryl-CoA synthase activity
Biological Processacetyl-CoA metabolic process
Biological Processfarnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxymethylglutaryl-CoA synthase ERG13
  • EC number
  • Short names
    HMG-CoA synthase
  • Alternative names
    • 3-hydroxy-3-methylglutaryl coenzyme A synthase ERG13
    • Ergosterol biosynthesis protein 13

Gene names

    • Name
      RGE13
    • ORF names
      FG09266, FGRAMPH1_01T27519

Organism names

Accessions

  • Primary accession
    I1RY35
  • Secondary accessions
    • A0A098DM80

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004546711-456Hydroxymethylglutaryl-CoA synthase ERG13

Expression

Induction

Expression is regulated by the Zn2-C6 fungal-type transcription factor FgSR which binds directly to the promoter.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    50,352
  • Last updated
    2012-06-13 v1
  • Checksum
    70DF1FAEFC94DE27
MSSRPQNIGIKAIELYFPSQYVDQVELEKFDGVSAGKYTIGLGQTKMSFCDDREDIYSFALTATSKLLKNYNIDPNSIGFLEVGTETLLDKSKSVKSVLMQLFGDNTNIEGVDTINACYGGTNAVFNAINWVESSAWDGRDAIVVAGDIALYAKGNARPTGGAGAVALLIGPNAPIVAEPGLRGTYMQHAYDFYKPDLTSEYPYVDGHYSVNCYSKALDAAYRAYCKREAKQANGTNGVTNGDASTKTGLDRFDYMAFHSPTCKLVQKSYARLLYHDYLANADSPVFAEVAPELRDMDYEKSLTDKVVEKTFMTLTKKRFQERVNPAIQVATNCGNMYCGSVWSGLASLISVVDNKDLEGKRIGLFSYGSGLAASFLSFRINGSVDKISDVLNIPSRLESRRAVPPETYDQMCDLRKQAHLQKDYTPKGDPSTILPGTYYLTKVDDMFKREYAIKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG970335
EMBL· GenBank· DDBJ
CEF82946.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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