I1RET0 · CFM5_GIBZE

Function

function

Suppresses host programmed cell death during infection by binding to Z.mays WAK17 isoform 2 and Z.mays LRR5, to prevent activation of Z.mays WAK17 isoform 1 and the downstream hypersensitive response.

Features

Showing features for binding site.

116120406080100120140160
TypeIDPosition(s)Description
Binding site60Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Biological Processeffector-mediated suppression of host innate immune response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Effector CFEM5

Gene names

    • Name
      CFEM5
    • ORF names
      FGRAMPH1_01T05255

Organism names

Accessions

  • Primary accession
    I1RET0

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Lipid-anchor, GPI-anchor
Secreted
Note: Localizes to the cell surface of spores.

Keywords

Phenotypes & Variants

Disruption phenotype

Decreases virulence in maize stalks (PubMed:36577386).
No sensitivity to Congo Red (cell wall disrupting agent) or sodium dodecyl sulfate (SDS) (membrane disrupting agent), and in vitro cell population growth appears normal (PubMed:36577386).

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_501012415224-161Effector CFEM5
Disulfide bond46↔78
Disulfide bond56↔63
Disulfide bond65↔100

Keywords

Interaction

Subunit

Interacts with Z.mays LRR5; the interaction is direct (PubMed:36577386).
Interacts with Z.mays WAK17 isoform 2; the interaction is direct (PubMed:36577386).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-126CFEM

Domain

The CFEM domain mediates interactions with host proteins.

Sequence similarities

Belongs to the RBT5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    161
  • Mass (Da)
    16,109
  • Last updated
    2012-06-13 v1
  • Checksum
    B55E32C6B37F401E
MFSLTKSVLFTSIVAIAAQATTAVSSPTQTSLPGLASQVPNCVAVCLRNLHESIGCDVGDIVCLCKSKASLISKVGLCVVGSQCDFEDASSSTDIVRDMCDLVAEDPGTAVIASASKVLDAVVASATTSDIEAPTSTNAAGLVAYDVVKVVVVGAAAAIAI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG970332
EMBL· GenBank· DDBJ
CEF74433.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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