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I1BT58 · I1BT58_RHIO9

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site520-525ITP (UniProtKB | ChEBI)
Binding site548Mg2+ (UniProtKB | ChEBI)
Binding site560ITP (UniProtKB | ChEBI)
Binding site576Mg2+ (UniProtKB | ChEBI)
Binding site576-577ITP (UniProtKB | ChEBI)
Binding site652-655ITP (UniProtKB | ChEBI)
Binding site675ITP (UniProtKB | ChEBI)
Binding site680-681ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular FunctionXTP diphosphatase activity
Biological Processacetyl-CoA biosynthetic process from acetate
Biological Processdeoxyribonucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      RO3G_04093

Organism names

Accessions

  • Primary accession
    I1BT58

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-30Helical

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-332AMP-dependent synthetase/ligase
Domain393-471AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.
Belongs to the HAM1 NTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    77,041
  • Last updated
    2012-06-13 v1
  • MD5 Checksum
    8523188772D00790F7E84F14E9A0F948
MPMVPEAIYAMIACARLGVVHSVIFAGFSFESLRDRINDCGARIILTADEGRRGGKNIAIKHIVDEALKNTPTIEHVLILRRTGLNIPLTPGRDLWWHEELAKARPYCPPIAVNAEHPLFLLHTSGSTGIAKGMIHATAGYLLGAAATVKYIFDYHEDDVYACIADIGWIIGHTYIVYGPLCLGATTVLFESTPTYPTPSRFWQMVENHKITQFYTAPTAIRALRRLGDQWIDKCDLSSLRVIGSVGEPINPETWEWYYQKIGQGQCAVVDTYWQTETGSIIITPLPGATATKPGSATFPFFGIKPVLLDLTTGAELKGNDVTGVLAISQPWPSMARSVYRNHDRYLNTYLNPYKGYYFTGDGATRDKDGYIWINGRVDDIINVSGHRLSTVEIESALSLHPSVAETAVVGGHDDLTGQCIHAFVILKSNLDDSKGLEKELALQVRKVIGSFATPKRIYVTNDLPRTRSGKIMRRILQKVINKEQDSLGDISALADHSVLNELVKHIMSAQQLPKLVFVTGNKNKLAEVQAILKGVIDVESHNLDLPELQGETQEIAKQKCKIAAETLNGPCITEDTSLCFNAMNGLPGPYIKWFLSSLGHDGLNKMLAGFDDKSAFALCTFGYCEGPGHEPVIFEGKTPGKIVPSRGPTTFGWDSVFQPDGYEQTYAELDKSIKNSISHRSRALDELKKYFQQKEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476733
EMBL· GenBank· DDBJ
EIE79388.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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