I0Z044 · I0Z044_COCSC
- ProteinMethylthioribose-1-phosphate isomerase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1818 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Catalytic activity
- S-methyl-5-thio-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)ribulose 1-phosphate
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 133 | Transition state stabilizer | |||
Active site | 213 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | S-methyl-5-thioribose kinase activity | |
Molecular Function | S-methyl-5-thioribose-1-phosphate isomerase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | L-methionine salvage from S-adenosylmethionine | |
Biological Process | phosphorelay signal transduction system | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylthioribose-1-phosphate isomerase
- EC number
- Short namesM1Pi ; MTR-1-P isomerase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Chlorophyta > core chlorophytes > Trebouxiophyceae > Trebouxiophyceae incertae sedis > Elliptochloris clade > Coccomyxa > Coccomyxa subellipsoidea
Accessions
- Primary accessionI0Z044
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5003637388 | 19-1818 | Methylthioribose-1-phosphate isomerase | ||
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 752-875 | Response regulatory | |||
Region | 909-1045 | Disordered | |||
Compositional bias | 914-938 | Basic and acidic residues | |||
Compositional bias | 941-1030 | Polar residues | |||
Region | 1078-1173 | Disordered | |||
Compositional bias | 1087-1171 | Polar residues | |||
Region | 1205-1275 | Disordered | |||
Compositional bias | 1238-1258 | Polar residues | |||
Compositional bias | 1292-1311 | Polar residues | |||
Region | 1292-1321 | Disordered | |||
Region | 1345-1375 | Disordered | |||
Compositional bias | 1347-1366 | Polar residues | |||
Region | 1484-1505 | Disordered | |||
Region | 1536-1601 | Disordered | |||
Compositional bias | 1556-1574 | Polar residues | |||
Domain | 1602-1644 | CCT | |||
Compositional bias | 1691-1706 | Acidic residues | |||
Region | 1691-1818 | Disordered | |||
Compositional bias | 1733-1804 | Polar residues | |||
Sequence similarities
Belongs to the ARR-like family.
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Belongs to the methylthioribose kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,818
- Mass (Da)190,701
- Last updated2012-06-13 v1
- ChecksumB7DE752902BE625B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 914-938 | Basic and acidic residues | |||
Compositional bias | 941-1030 | Polar residues | |||
Compositional bias | 1087-1171 | Polar residues | |||
Compositional bias | 1238-1258 | Polar residues | |||
Compositional bias | 1292-1311 | Polar residues | |||
Compositional bias | 1347-1366 | Polar residues | |||
Compositional bias | 1556-1574 | Polar residues | |||
Compositional bias | 1691-1706 | Acidic residues | |||
Compositional bias | 1733-1804 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGSI01000006 EMBL· GenBank· DDBJ | EIE24013.1 EMBL· GenBank· DDBJ | Genomic DNA |