I0Z044 · I0Z044_COCSC

Function

function

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.

Features

Showing features for site, active site.

Type
IDPosition(s)Description
Site133Transition state stabilizer
Active site213Proton donor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionS-methyl-5-thioribose kinase activity
Molecular FunctionS-methyl-5-thioribose-1-phosphate isomerase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine
Biological Processphosphorelay signal transduction system
Biological Processrhythmic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylthioribose-1-phosphate isomerase
  • EC number
  • Short names
    M1Pi
    ; MTR-1-P isomerase
  • Alternative names
    • S-methyl-5-thioribose-1-phosphate isomerase
    • Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein

Gene names

    • ORF names
      COCSUDRAFT_65695

Organism names

Accessions

  • Primary accession
    I0Z044

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_500363738819-1818Methylthioribose-1-phosphate isomerase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain752-875Response regulatory
Region909-1045Disordered
Compositional bias914-938Basic and acidic residues
Compositional bias941-1030Polar residues
Region1078-1173Disordered
Compositional bias1087-1171Polar residues
Region1205-1275Disordered
Compositional bias1238-1258Polar residues
Compositional bias1292-1311Polar residues
Region1292-1321Disordered
Region1345-1375Disordered
Compositional bias1347-1366Polar residues
Region1484-1505Disordered
Region1536-1601Disordered
Compositional bias1556-1574Polar residues
Domain1602-1644CCT
Compositional bias1691-1706Acidic residues
Region1691-1818Disordered
Compositional bias1733-1804Polar residues

Sequence similarities

Belongs to the ARR-like family.
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Belongs to the methylthioribose kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,818
  • Mass (Da)
    190,701
  • Last updated
    2012-06-13 v1
  • Checksum
    B7DE752902BE625B
MAVRGAPAIAIAAALALAAELVNQGGGAQFESAQAAYQKITEQLEYLVTSRPTAVNLQIAANRLSAIAKKEASVEGGSGVSVTIAVISAADAMFKDDITANKTMGKLGAEGILAELASRGGSSGAGVRVLTHCNTGSLATAAYGTALGVVRALHAAGHLQHAFCTETRPYNQGSRLTAYELVHDGLPAMLIADSAAAALMAQRKVDAIVVGADRIAANGDTANKIGTFSLAVNAAHHGIPFYIAAPTMTVDPSLPDGTLIPIEERSSTELTHHQGQRVAAPGINVWNPAFDVTPASLITGIITEQGIIQQRDGAIDVNSFLREHGLLEAEESRDNGAVTSVPTSKIPGFRALNLETVKEYVAERPDLGERVGPSGSKDSWTVREVGDGNINFVYIVEGPSGALVVKQGLPYIRIAHDWPLTQERARFEAEALREEARHCPEHIPELYHFDAALCLLVMQYLPPPHLVLRPALTAGHSFPSLARHIAHFMATTLFRTSLLALDSKAWRELVGRFENMDICRLTEQVIFTDPYYSAPMNRHTSPQLDDLADAFQHDVAAKAAIAALKAKFVQQRQALLHGDLHTGSLMVTADTTYVIDAEFAFAGPIAFDVGKMVANLLIAFFAGGGLQTAEQPRTAQRRWLLQATVEMWELFKTEFRELWNAALKDKKAGDLCPAPLFGNDAPAGPDALQAVQEAFFAGLLPDVLGFAGAVIIRRILGIAHVVDYESITDVDARHPGGAGAAAVDILSPQSLRVLVVDSKASARQEVVALLRKCTYQVMEVKSTAEALQLLKDQQARDGAPGVDLILKEHDPPAANACRLLRRTLEDDVLRTVPVVVMSSQEDRDVMVACLQLGAADYMIRPLRHNELRNLWARVYWWRRAFYLQQQATHALGAKEHSLPGLKLRYYPSLSQSSDESEETKRCQQALKPVNREEMERSGEGSAPNGSGNGGANGSGNCSKDGNGNSRVHPGSGGNGNGNSATKQCEGSNQPNGESGNNGNGDSATKAGNLHFGNGNSGNDASTSRQEVAALQGTAQGGKRYRMAQEAGAEMRGAKCEGGAEAGMEPKLWPADGVRPVKLYRGGHSRSDAVNDNGNGVVGSTTGGQAATLPGSSSRQDSKPNGTNGGDGSSGQDTGNGNGAMTANGNGGSTSHRMELPSSAEGAQTGGPHQSTRLHSEAGGFRAYIGQAHKRKASEIATVSEVPLNRASSQALARNSTAAPRPADCTEAGSMARAGGAASNTLGPQTTGSTPTSASEDTRMVGSDGKGTSMPLRLGSKSGSLDQVQVQWPHNESAQMQQRLQASAQRQNSGPAPQMPGFRGPGNFNYFGMPPPNFPMPGPFWPGMPNPMGQVSGQSSGQGSGQGGFQEGNPQFDAFFGPFGAQQMAAAMAAAAGAASTGNREREAAAAAAQQQQQQQHHFAMILQQQQAQQQQMFLQQYGLAASNMMQQMAAGGPWQQSNRAQPGSPSAAAAAQFAAAFPFGNPNGSGGARSVPSYPAHPMASRGGPMQQYAAARAAAAATAASNGARPGLMHSAPAAAAGNAGATHGGAGVNNGATSRAPPGLQQNGTQQNGAEEDAQIGVKAEQGADVLTSGTANATGRERRMQALHKYKQKRKNLNFTKKIRYESRKQLAQARPRVKGQFVRMASGAIDADAVEAAVEADAAEMLGDLPNLAAAADAALAAAKVAAEDEGMDFQDDDESVDNEEEIKEEAAAKWQAGAAQPPEEDDDDNVVNSPQDIFNRVAGPASNSHGQHSGSRLQSHGIAMHPHSNSNRTASPVVVSNTHGKVAVNGNGSSDSGSNSPDIKDGPGESPDADMEQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias914-938Basic and acidic residues
Compositional bias941-1030Polar residues
Compositional bias1087-1171Polar residues
Compositional bias1238-1258Polar residues
Compositional bias1292-1311Polar residues
Compositional bias1347-1366Polar residues
Compositional bias1556-1574Polar residues
Compositional bias1691-1706Acidic residues
Compositional bias1733-1804Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGSI01000006
EMBL· GenBank· DDBJ
EIE24013.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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