I0CME7 · HYAL_CONCN
- ProteinHyaluronidase conohyal-Cn1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids448 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. In venom, they are known to enhance diffusion of the venom by degrading the extracellular matrix.
Miscellaneous
Found in both injectable (milked) (IV) and dissected venom (DV).
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 151 | Proton donor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | hyalurononglucosaminidase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | hyaluronan catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHyaluronidase conohyal-Cn1
- EC number
- Short namesHya
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Pionoconus
Accessions
- Primary accessionI0CME7
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 78 | |||||
Sequence: D → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MRAVVVVTGLVVVVVATA | ||||||
Propeptide | PRO_0000419902 | 19-33 | ||||
Sequence: LSLPNHDVKSATSSR | ||||||
Chain | PRO_0000419903 | 34-448 | Hyaluronidase conohyal-Cn1 | |||
Sequence: SSSDYQGSSGDDCDEGLPPPDQPFRVVWNHPDNCERIKLHLPLDDYGIIFNKLRVFLGEEIQTLYDTGPWPYISETGKFINGGLPQSFNHPDNDGETQRILKKHRPENFTGLGVLDFETWRAIYSTNFGPMTIYQNESVKLVKEQHPDYDQKKLTKVAEKEWQQAAKDIMSNKLKIAQEVMPRGHWGYYLYPRTWDNKRDTKFRNDKINWLWRQSTGLYPSIYIYDFSKTESAITKFVSDTVGEAVRVQKEFSPPNTPIYPYVMFQTMDNIFHYEDHLKISLGLSAKMGAAGVVLWGTSKHYKESTRQWQCQQLQEHIRTVLGPLVKNVTQMMTDCSRAICEGHGRCVHNSHDVILGETESQRLSDLCSTRQSRFRDYHCRCYSAWEGACCQTLRPSRCQKREQRNVHGGGDLID | ||||||
Disulfide bond | 67↔344 | |||||
Sequence: CERIKLHLPLDDYGIIFNKLRVFLGEEIQTLYDTGPWPYISETGKFINGGLPQSFNHPDNDGETQRILKKHRPENFTGLGVLDFETWRAIYSTNFGPMTIYQNESVKLVKEQHPDYDQKKLTKVAEKEWQQAAKDIMSNKLKIAQEVMPRGHWGYYLYPRTWDNKRDTKFRNDKINWLWRQSTGLYPSIYIYDFSKTESAITKFVSDTVGEAVRVQKEFSPPNTPIYPYVMFQTMDNIFHYEDHLKISLGLSAKMGAAGVVLWGTSKHYKESTRQWQC | ||||||
Glycosylation | 141 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 169 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 361 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 369↔380 | |||||
Sequence: CSRAICEGHGRC | ||||||
Disulfide bond | 374↔413 | |||||
Sequence: CEGHGRCVHNSHDVILGETESQRLSDLCSTRQSRFRDYHC | ||||||
Disulfide bond | 415↔424 | |||||
Sequence: CYSAWEGACC |
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Expressed by the venom duct.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-42 | Polar residues | ||||
Sequence: VKSATSSRSSSDYQGSS | ||||||
Region | 26-55 | Disordered | ||||
Sequence: VKSATSSRSSSDYQGSSGDDCDEGLPPPDQ | ||||||
Domain | 413-424 | EGF-like | ||||
Sequence: CRCYSAWEGACC |
Sequence similarities
Belongs to the glycosyl hydrolase 56 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length448
- Mass (Da)51,427
- Last updated2012-06-13 v1
- Checksum57E4073753DDB803
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-42 | Polar residues | ||||
Sequence: VKSATSSRSSSDYQGSS |
Keywords
- Technical term