I0CME7 · HYAL_CONCN

Function

function

Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. In venom, they are known to enhance diffusion of the venom by degrading the extracellular matrix.

Miscellaneous

Found in both injectable (milked) (IV) and dissected venom (DV).

Catalytic activity

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
    EC:3.2.1.35 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

144850100150200250300350400
TypeIDPosition(s)Description
Active site151Proton donor

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionhyalurononglucosaminidase activity
Biological Processcarbohydrate metabolic process
Biological Processhyaluronan catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Hyaluronidase conohyal-Cn1
  • EC number
  • Short names
    Hya
  • Alternative names
    • Hyaluronoglucosaminidase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Pionoconus

Accessions

  • Primary accession
    I0CME7

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant78

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
PropeptidePRO_000041990219-33
ChainPRO_000041990334-448Hyaluronidase conohyal-Cn1
Disulfide bond67↔344
Glycosylation141N-linked (GlcNAc...) asparagine
Glycosylation169N-linked (GlcNAc...) asparagine
Glycosylation361N-linked (GlcNAc...) asparagine
Disulfide bond369↔380
Disulfide bond374↔413
Disulfide bond415↔424

Keywords

PTM databases

Expression

Tissue specificity

Expressed by the venom duct.

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias26-42Polar residues
Region26-55Disordered
Domain413-424EGF-like

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    448
  • Mass (Da)
    51,427
  • Last updated
    2012-06-13 v1
  • Checksum
    57E4073753DDB803
MRAVVVVTGLVVVVVATALSLPNHDVKSATSSRSSSDYQGSSGDDCDEGLPPPDQPFRVVWNHPDNCERIKLHLPLDDYGIIFNKLRVFLGEEIQTLYDTGPWPYISETGKFINGGLPQSFNHPDNDGETQRILKKHRPENFTGLGVLDFETWRAIYSTNFGPMTIYQNESVKLVKEQHPDYDQKKLTKVAEKEWQQAAKDIMSNKLKIAQEVMPRGHWGYYLYPRTWDNKRDTKFRNDKINWLWRQSTGLYPSIYIYDFSKTESAITKFVSDTVGEAVRVQKEFSPPNTPIYPYVMFQTMDNIFHYEDHLKISLGLSAKMGAAGVVLWGTSKHYKESTRQWQCQQLQEHIRTVLGPLVKNVTQMMTDCSRAICEGHGRCVHNSHDVILGETESQRLSDLCSTRQSRFRDYHCRCYSAWEGACCQTLRPSRCQKREQRNVHGGGDLID

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias26-42Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN697596
EMBL· GenBank· DDBJ
AFH78528.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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