I0B8M2 · I0B8M2_DROME
- ProteinHistidine decarboxylase
- GeneHdc
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids847 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | histidine decarboxylase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | amino acid metabolic process | |
Biological Process | carboxylic acid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidine decarboxylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionI0B8M2
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 304 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 575-602 | Polar residues | ||||
Sequence: GNGATRTSTTNSYGHTTSAAQANSERQA | ||||||
Region | 575-662 | Disordered | ||||
Sequence: GNGATRTSTTNSYGHTTSAAQANSERQASIQEDNEESPEETELLSLCRTSNVPSPEHAHSLSTPSRSCSSSSHSLIHSLTQSSPRSSP | ||||||
Compositional bias | 617-662 | Polar residues | ||||
Sequence: LLSLCRTSNVPSPEHAHSLSTPSRSCSSSSHSLIHSLTQSSPRSSP | ||||||
Region | 769-798 | Disordered | ||||
Sequence: QSQSLGNNSSTESSSLSGGATPTPTPMSSL | ||||||
Region | 813-847 | Disordered | ||||
Sequence: SQPMLSAHGIGEGQREQGSDSDATVCSTTSSMESL | ||||||
Compositional bias | 829-847 | Polar residues | ||||
Sequence: QGSDSDATVCSTTSSMESL |
Sequence similarities
Belongs to the group II decarboxylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length847
- Mass (Da)94,036
- Last updated2012-06-13 v1
- ChecksumC04F32F01C176951
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q05733 | DCHS_DROME | Hdc | 847 | ||
A0A0B4KEQ1 | A0A0B4KEQ1_DROME | Hdc | 619 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 575-602 | Polar residues | ||||
Sequence: GNGATRTSTTNSYGHTTSAAQANSERQA | ||||||
Compositional bias | 617-662 | Polar residues | ||||
Sequence: LLSLCRTSNVPSPEHAHSLSTPSRSCSSSSHSLIHSLTQSSPRSSP | ||||||
Compositional bias | 829-847 | Polar residues | ||||
Sequence: QGSDSDATVCSTTSSMESL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BT133422 EMBL· GenBank· DDBJ | AFH58719.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AGB93388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AHN56072.1 EMBL· GenBank· DDBJ | Genomic DNA |