H9XNX5 · H9XNX5_9EUCA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • TR050EK
    • TR256EK
    • Prt
    • Dft
    • Gty
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Dendrobranchiata > Penaeoidea > Penaeidae > Penaeus

Accessions

  • Primary accession
    H9XNX5

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-218Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    218
  • Mass (Da)
    23,307
  • Last updated
    2012-06-13 v1
  • Checksum
    80817A12DBB5D28A
LYFIFGAWAGMVGTALSLIIRAELGQPGSLIGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSGMVESGVGTGWTVYPPLSAGIAHAGASVDLGIFSLHLAGVSSILGAVNFMTTVINMRSTGMTMDRMPLFVWAVFITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPVLYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue218

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ623953
EMBL· GenBank· DDBJ
AFH00927.1
EMBL· GenBank· DDBJ
Genomic DNA
KC311402
EMBL· GenBank· DDBJ
AGA83620.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789234
EMBL· GenBank· DDBJ
AGN48690.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789238
EMBL· GenBank· DDBJ
AGN48694.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789239
EMBL· GenBank· DDBJ
AGN48695.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789240
EMBL· GenBank· DDBJ
AGN48696.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789241
EMBL· GenBank· DDBJ
AGN48697.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789242
EMBL· GenBank· DDBJ
AGN48698.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789243
EMBL· GenBank· DDBJ
AGN48699.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789245
EMBL· GenBank· DDBJ
AGN48701.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789246
EMBL· GenBank· DDBJ
AGN48702.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789247
EMBL· GenBank· DDBJ
AGN48703.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789248
EMBL· GenBank· DDBJ
AGN48704.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789251
EMBL· GenBank· DDBJ
AGN48707.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789252
EMBL· GenBank· DDBJ
AGN48708.1
EMBL· GenBank· DDBJ
Genomic DNA
KC789253
EMBL· GenBank· DDBJ
AGN48709.1
EMBL· GenBank· DDBJ
Genomic DNA
KU324638
EMBL· GenBank· DDBJ
AMD36233.1
EMBL· GenBank· DDBJ
Genomic DNA
KU324639
EMBL· GenBank· DDBJ
AMD36234.1
EMBL· GenBank· DDBJ
Genomic DNA
KU324640
EMBL· GenBank· DDBJ
AMD36235.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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