H9NG67 · H9NG67_9CARA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Trechinae > Pogonini > Pogonus

Accessions

  • Primary accession
    H9NG67

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,494
  • Last updated
    2012-06-13 v1
  • MD5 Checksum
    ED69E03BDE36B7443D8AF0A85CE787ED
TLYFIFGAWAGMVGTSLSMLIRAELGNPGSLIGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLMSSMVESGAGTGWTVYPPLSSAIAHSGASVDLAIFSLHLAGVSSILGAVNFITTIINMRSIGMTFDRMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN171148
EMBL· GenBank· DDBJ
AFF58441.1
EMBL· GenBank· DDBJ
Genomic DNA
KM441354
EMBL· GenBank· DDBJ
AJB87069.1
EMBL· GenBank· DDBJ
Genomic DNA
KM441469
EMBL· GenBank· DDBJ
AJB87184.1
EMBL· GenBank· DDBJ
Genomic DNA
KM442024
EMBL· GenBank· DDBJ
AJB87739.1
EMBL· GenBank· DDBJ
Genomic DNA
KM442131
EMBL· GenBank· DDBJ
AJB87846.1
EMBL· GenBank· DDBJ
Genomic DNA
KM442358
EMBL· GenBank· DDBJ
AJB88073.1
EMBL· GenBank· DDBJ
Genomic DNA
KM442523
EMBL· GenBank· DDBJ
AJB88238.1
EMBL· GenBank· DDBJ
Genomic DNA
KM442971
EMBL· GenBank· DDBJ
AJB88686.1
EMBL· GenBank· DDBJ
Genomic DNA
KM445281
EMBL· GenBank· DDBJ
AJB90996.1
EMBL· GenBank· DDBJ
Genomic DNA
KM445835
EMBL· GenBank· DDBJ
AJB91550.1
EMBL· GenBank· DDBJ
Genomic DNA
KM448767
EMBL· GenBank· DDBJ
AJB94482.1
EMBL· GenBank· DDBJ
Genomic DNA
KM448932
EMBL· GenBank· DDBJ
AJB94647.1
EMBL· GenBank· DDBJ
Genomic DNA
KM449159
EMBL· GenBank· DDBJ
AJB94874.1
EMBL· GenBank· DDBJ
Genomic DNA
KM450164
EMBL· GenBank· DDBJ
AJB95879.1
EMBL· GenBank· DDBJ
Genomic DNA
KM450768
EMBL· GenBank· DDBJ
AJB96483.1
EMBL· GenBank· DDBJ
Genomic DNA
KM450913
EMBL· GenBank· DDBJ
AJB96628.1
EMBL· GenBank· DDBJ
Genomic DNA
KM451995
EMBL· GenBank· DDBJ
AJB97710.1
EMBL· GenBank· DDBJ
Genomic DNA
KU907256
EMBL· GenBank· DDBJ
ARB53676.1
EMBL· GenBank· DDBJ
Genomic DNA
KU912466
EMBL· GenBank· DDBJ
ARB58886.1
EMBL· GenBank· DDBJ
Genomic DNA
KU915332
EMBL· GenBank· DDBJ
ARB61752.1
EMBL· GenBank· DDBJ
Genomic DNA
KU918208
EMBL· GenBank· DDBJ
ARB64628.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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