H9LSN3 · H9LSN3_CROCR

Function

function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Molecular Functionproton transmembrane transporter activity
Biological Processproton motive force-driven ATP synthesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP synthase protein 8

Gene names

    • Name
      ATP8

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • CC8
    • CC9
    • Kira
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Hyaenidae > Crocuta

Accessions

  • Primary accession
    H9LSN3

Subcellular Location

Membrane
; Single-pass membrane protein
Mitochondrion membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
Interacts with PRICKLE3

Family & Domains

Sequence similarities

Belongs to the ATPase protein 8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    67
  • Mass (Da)
    7,996
  • Last updated
    2012-06-13 v1
  • Checksum
    8B67A836A5027BA7
MPQLDTSTWFITIMSMIITLFIMFQLKISKHTHPWNPEPKPPMTLKQPSPWEKKWTKIYSPLSLPQQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JF894377
EMBL· GenBank· DDBJ
AEG77596.1
EMBL· GenBank· DDBJ
Genomic DNA
JF894378
EMBL· GenBank· DDBJ
AEG77609.1
EMBL· GenBank· DDBJ
Genomic DNA
JF894379
EMBL· GenBank· DDBJ
AEG77622.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320451
EMBL· GenBank· DDBJ
QIP89170.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320456
EMBL· GenBank· DDBJ
QIP89235.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320459
EMBL· GenBank· DDBJ
QIP89274.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320461
EMBL· GenBank· DDBJ
QIP89300.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320462
EMBL· GenBank· DDBJ
QIP89313.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320463
EMBL· GenBank· DDBJ
QIP89326.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320464
EMBL· GenBank· DDBJ
QIP89339.1
EMBL· GenBank· DDBJ
Genomic DNA
MN320467
EMBL· GenBank· DDBJ
QIP89378.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp