H9FWM2 · H9FWM2_MACMU
- Protein4'-phosphopantetheine phosphatase
- GenePANK4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids773 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
Catalytic activity
- (R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphateThis reaction proceeds in the forward direction.
- (R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphateThis reaction proceeds in the forward direction.
- (R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Activity regulation
Activity is strongly promoted by Co2+, Ni2+, Mg2+ and Mn2+. Activity is inhibited by EDTA.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4'-phosphopantetheine phosphatase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionH9FWM2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 453-759 | Damage-control phosphatase ARMT1-like metal-binding | |||
Sequence similarities
Belongs to the type II pantothenate kinase family.
In the N-terminal section; belongs to the type II pantothenate kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length773
- Mass (Da)86,025
- Last updated2016-11-30 v1
- MD5 ChecksumBB17A06F232B66E558B4F3FC0816E3DC
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8ACD8 | A0A5F8ACD8_MACMU | PANK4 | 750 | ||
A0A5F7ZAW0 | A0A5F7ZAW0_MACMU | PANK4 | 745 | ||
A0A5F8ALR6 | A0A5F8ALR6_MACMU | PANK4 | 745 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JU335278 EMBL· GenBank· DDBJ | AFE79031.1 EMBL· GenBank· DDBJ | mRNA | ||
JU471673 EMBL· GenBank· DDBJ | AFH28477.1 EMBL· GenBank· DDBJ | mRNA |