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H9FWM2 · H9FWM2_MACMU

Function

function

Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Activity regulation

Activity is strongly promoted by Co2+, Ni2+, Mg2+ and Mn2+. Activity is inhibited by EDTA.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4'-phosphopantetheine phosphatase
  • EC number

Gene names

    • Name
      PANK4

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    H9FWM2
  • Secondary accessions
    • F7GTZ5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with PKM.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain453-759Damage-control phosphatase ARMT1-like metal-binding

Sequence similarities

Belongs to the type II pantothenate kinase family.
In the N-terminal section; belongs to the type II pantothenate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    773
  • Mass (Da)
    86,025
  • Last updated
    2016-11-30 v1
  • MD5 Checksum
    BB17A06F232B66E558B4F3FC0816E3DC
MAECGASGSGSSGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSFDHSGKDTERDHEPPYEISVQEEITARLHFIKFENTYIEACLDFIKDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFVYQKDSDPEFRFQTNHPHIFPYLLVNIGSGVSIVKVETEDRFEWVGGSSIGGGTFWGLGALLTKTKKFDELLHLASRGQHSNVDMLVRDVYGGAHQTLGLSGNLIASSFGKSATADQEFSKEDMAKSLLHMISNDIGQLACLHARLHSLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAGSSGLMSTSPELGPAQRARSGTFDLLEMDRLERPLVNLPLLLDPPSYVPDTVDLTDDALARKYWLTCFEEALDGVVKRAVASQPDSVDAAERAEKFRQKYWNKLQTLRQQPFAYGTLTVRSLLDTREHCLNEFNFPDPYSKVKQRENGVALRCFPGVVRSLDTLGWEERQLALVKGLLAGNVFDWGAKAVSDVLESDPYFGFEEAKRKLQERPWLVDSYSEWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLLRGTEVILACNSGPALNDVTHGESLIVAERIAGMDPVVHSALREERLLLVQTGSSSPCLDLSRLDKGLAALVRERGADLVVIEGMGRAVHTNYHAALCCESLKLAVIKNAWLAERLGGRLFSVIFKYEVPAE

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8ACD8A0A5F8ACD8_MACMUPANK4750
A0A5F7ZAW0A0A5F7ZAW0_MACMUPANK4745
A0A5F8ALR6A0A5F8ALR6_MACMUPANK4745

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JU335278
EMBL· GenBank· DDBJ
AFE79031.1
EMBL· GenBank· DDBJ
mRNA
JU471673
EMBL· GenBank· DDBJ
AFH28477.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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