H9FUW3 · H9FUW3_MACMU

Function

function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionidentical protein binding
Molecular FunctionNF-kappaB binding
Molecular Functionnuclear localization sequence binding
Molecular Functionprotein sequestering activity
Molecular Functiontranscription regulator inhibitor activity
Molecular Functionubiquitin protein ligase binding
Biological ProcessB cell receptor signaling pathway
Biological Processcanonical NF-kappaB signal transduction
Biological Processcellular response to tumor necrosis factor
Biological Processcytoplasmic sequestering of NF-kappaB
Biological Processinterleukin-1-mediated signaling pathway
Biological Processlipopolysaccharide-mediated signaling pathway
Biological Processnegative regulation of canonical NF-kappaB signal transduction
Biological Processnegative regulation of lipid storage
Biological Processnegative regulation of macrophage derived foam cell differentiation
Biological Processnegative regulation of myeloid cell differentiation
Biological Processnegative regulation of Notch signaling pathway
Biological Processnon-canonical NF-kappaB signal transduction
Biological ProcessNotch signaling pathway
Biological Processnucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Processnucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Processpositive regulation of cholesterol efflux
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of protein metabolic process
Biological Processpositive regulation of transcription initiation by RNA polymerase II
Biological Processprotein import into nucleus
Biological Processregulation of cell population proliferation
Biological Processresponse to exogenous dsRNA
Biological Processresponse to muramyl dipeptide
Biological Processresponse to muscle stretch
Biological Processtoll-like receptor 4 signaling pathway
Biological Processtumor necrosis factor-mediated signaling pathway

Names & Taxonomy

Protein names

  • Recommended name
    NF-kappa-B inhibitor alpha
  • Alternative names
    • I-kappa-B-alpha

Gene names

    • Name
      NFKBIA

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    H9FUW3
  • Secondary accessions
    • A0A1D5R1G4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, repeat.

Type
IDPosition(s)Description
Region1-39Disordered
Compositional bias11-39Basic and acidic residues
Repeat110-142ANK
Repeat182-214ANK
Repeat216-248ANK

Sequence similarities

Belongs to the NF-kappa-B inhibitor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    317
  • Mass (Da)
    35,593
  • Last updated
    2016-11-30 v1
  • Checksum
    088B3F882678674F
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGAEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias11-39Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JU334669
EMBL· GenBank· DDBJ
AFE78422.1
EMBL· GenBank· DDBJ
mRNA
JU475718
EMBL· GenBank· DDBJ
AFH32522.1
EMBL· GenBank· DDBJ
mRNA
JV047163
EMBL· GenBank· DDBJ
AFI37234.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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