H9EVY5 · H9EVY5_MACMU

Function

function

Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity
Molecular Functionpolyprenol reductase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process
Biological Processpolyprenol catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      SRD5A3

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    H9EVY5

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-46Helical
Transmembrane79-100Helical
Transmembrane120-139Helical
Transmembrane160-181Helical
Transmembrane201-218Helical
Transmembrane278-299Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain199-3183-oxo-5-alpha-steroid 4-dehydrogenase C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    36,472
  • Last updated
    2016-11-30 v1
  • Checksum
    E8D61583387FEBBE
MAPWAEAELSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEPPRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLSQSLFLGAPFPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSIRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQVPMDGRNAYVTGKNVLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNFTWWLVVTNVFFSQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8ACS8A0A5F8ACS8_MACMUSRD5A3308
F6R6P8F6R6P8_MACMUSRD5A3306
A0A5F8A3U7A0A5F8A3U7_MACMUSRD5A3346

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JU322788
EMBL· GenBank· DDBJ
AFE66544.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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