H9C5V7 · H9C5V7_EBVG
- ProteinLatent membrane protein 1
- GeneLMP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids386 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Biological Process | symbiont-mediated activation of host NF-kappaB cascade | |
Biological Process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | transformation of host cell by virus | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLatent membrane protein 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Gammaherpesvirinae > Lymphocryptovirus > Lymphocryptovirus humangamma4
- Virus hosts
Accessions
- Primary accessionH9C5V7
Subcellular Location
UniProt Annotation
GO Annotation
Host cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-44 | Helical | ||||
Sequence: LSSSLGLVLLLLLLALLFWLYIVM | ||||||
Transmembrane | 50-72 | Helical | ||||
Sequence: GALLVLYSFALMLIIIILIIFIF | ||||||
Transmembrane | 79-98 | Helical | ||||
Sequence: PLGALCLLLLMITLLLIALW | ||||||
Transmembrane | 104-126 | Helical | ||||
Sequence: ALYLGIVLFIFGCLLVLGVWIYL | ||||||
Transmembrane | 138-159 | Helical | ||||
Sequence: WQLLAFFLAFFLDLILLIIALY | ||||||
Transmembrane | 165-186 | Helical | ||||
Sequence: WTLLVDLLWLLLFLAILIWMYY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 194-386 | Disordered | ||||
Sequence: EHHHDDSLPHPQQATHDSSNESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDDTDDNGPQDPDNTDDNGPHDPLPQDPDNTDNNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVQNKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD | ||||||
Compositional bias | 282-296 | Polar residues | ||||
Sequence: DPDNTDNNGPQDPDN |
Sequence similarities
Belongs to the herpesviridae LMP-1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)42,098
- Last updated2012-05-16 v1
- ChecksumDF5275E30E37A13F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 282-296 | Polar residues | ||||
Sequence: DPDNTDNNGPQDPDN |