H8XX86 · H8XX86_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3387 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1525 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1549 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1609 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2543 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2573 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2574 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2591 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2592 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2618 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2619 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2706 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2925 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2929 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2934 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2937 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3200 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3216 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3335 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionH8XX86
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 239-256 | Helical | ||||
Sequence: WILRNPGFALLAGFMAYM | ||||||
Transmembrane | 722-746 | Helical | ||||
Sequence: VYTTMFGGVSWMIRILIGFLVLWIG | ||||||
Transmembrane | 1159-1177 | Helical | ||||
Sequence: ILAVVITLCAIILGGLTWM | ||||||
Transmembrane | 1197-1218 | Helical | ||||
Sequence: QTHLAIMAVFKMSPGYVLGVFL | ||||||
Transmembrane | 1286-1305 | Helical | ||||
Sequence: LVMAWRTIMAVLFVVTLIPL | ||||||
Transmembrane | 1317-1336 | Helical | ||||
Sequence: WVEITALILGAQALPVYLMT | ||||||
Transmembrane | 1348-1366 | Helical | ||||
Sequence: LNEGIMAVGLVSLLGSALL | ||||||
Transmembrane | 1372-1389 | Helical | ||||
Sequence: LAGPMVAGGLLLAAYVMS | ||||||
Transmembrane | 1441-1468 | Helical | ||||
Sequence: LLVKLALITVSGLYPLAIPITMTLWYMW | ||||||
Transmembrane | 2147-2165 | Helical | ||||
Sequence: LMLVALLGAMTAGIFLFFM | ||||||
Transmembrane | 2172-2190 | Helical | ||||
Sequence: KLSMGLITIAVASGLLWVA | ||||||
Transmembrane | 2196-2213 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 2225-2242 | Helical | ||||
Sequence: QLIYVILTILTIIGLIAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 282↔309 | |||||
Sequence: CVGVGNRDFVEGVSGGAWVDLVLEHGGC | ||||||
Disulfide bond | 339↔395 | |||||
Sequence: CIEALISNITTATRCPTQGEPYLKEEQDQQYICRRDVVDRGWGNGCGLFGKGGVVTC | ||||||
Disulfide bond | 353↔384 | |||||
Sequence: CPTQGEPYLKEEQDQQYICRRDVVDRGWGNGC | ||||||
Disulfide bond | 371↔400 | |||||
Sequence: CRRDVVDRGWGNGCGLFGKGGVVTCAKFSC | ||||||
Disulfide bond | 464↔564 | |||||
Sequence: CEPRSGIDFNEMILMKMKKKTWLVHKQWFLDLPLPWTTGADTSEVHWNYKERMVTFKVPHAKRQDVTVLGSQEGAMHSALAGATEVDSGDGNHMFAGHLKC | ||||||
Disulfide bond | 581↔612 | |||||
Sequence: CSGKFSIDKEMAETQHGTTVVKVKYEGAGAPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1345-1474 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAVGLVSLLGSALLKNDVPLAGPMVAGGLLLAAYVMSGSSVDLSLEKAANVQWDEMADITGSSPIIEVKQDEDGSFSIRDVEETNMITLLVKLALITVSGLYPLAIPITMTLWYMWQVKTQR | ||||||
Domain | 1475-1652 | Peptidase S7 | ||||
Sequence: SGALWDVPSPAATQKAALSEGVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHETGRLEPSWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFKTLTGEIGAVTLDFKPGTSGSPIINRKGKVIGLYGNGVVTKSGDYVSAITQAERIGEPDYEV | ||||||
Domain | 1654-1810 | Helicase ATP-binding | ||||
Sequence: EDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRGLPIRYQTPAVKSEHTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAHFTDPSSVAARGYISTRVEMGEAAAIFMTATPPGATDPFPQSNSPIEDIE | ||||||
Domain | 1805-1986 | Helicase C-terminal | ||||
Sequence: PIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSGKKVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPE | ||||||
Domain | 2489-2751 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGTTGETLGEKWKRQLNSLDRKEFEEYKRSGILEVDRTEAKSALKDGSKIKHAVSRGSSKIRWIVERGMVKPKGKVVDLGCGRGGWSYYMATLKNVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGVDVFYKPTEQVDTLLCDIGESSSNPTIEEGRTLRVLKMVEPWLSSKPEFCIKVLNPYMPTVIEELEKLQRKHGGNLVRCPLSRNSTHEMYWVSGASGNIVSSVNTTSKMLLNRFTTRHRKPTYEKDVDLGAGTRS | ||||||
Domain | 3015-3165 | RdRp catalytic | ||||
Sequence: DLMYADDTAGWDTRITEDDLQNEELITEQMAPHHKILAKAIFKLTYQNKVVKVLRPTPRGAVMDIISRKDQRGSGQVGTYGLNTFTNMEVQLIRQMEAEGVITQDDMQNPKGLKERVEKWLRECGVDRLKRMAISGDDCVVKPLDERFGTS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,387
- Mass (Da)378,500
- Last updated2012-05-16 v1
- ChecksumDB085B8D82C847EA