H8ESN0 · KASA_MYCTE
- Protein3-oxoacyl-[acyl-carrier-protein] synthase 1
- GenekasA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids416 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor. Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length.
Catalytic activity
- an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + malonyl-[ACP] + H+ = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
Pathway
Lipid metabolism; mycolic acid biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 171 | For beta-ketoacyl synthase activity | |||
Active site | 311 | For beta-ketoacyl synthase activity | |||
Binding site | 311 | substrate | |||
Active site | 345 | For beta-ketoacyl synthase activity | |||
Binding site | 345 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-oxoacyl-[acyl-carrier-protein] synthase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionH8ESN0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000422686 | 1-416 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | ||
Expression
Induction
Repressed by Rip1 and independently by the metal chelator phenanthroline.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-415 | Ketosynthase family 3 (KS3) | |||
Sequence similarities
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)43,316
- Last updated2013-06-26 v2
- ChecksumD2187BE2F0B56C7F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012340 EMBL· GenBank· DDBJ | BAL66261.1 EMBL· GenBank· DDBJ | Genomic DNA |