The authors show that ERG-28 an endoplasmic reticulum (ER) membrane protein promotes the trafficking of SLO-1 BK channels from the ER to the plasma membrane by shielding them from premature degradation.
SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins CTN-1 and DYB-1 are crucial for normal SLO-1 cluster formation
This study shows cellular and whole organismal behavioral responses to ethanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concentrations in humans.
an interaction between BK and EAG family K(+) channels produces the muscle excitability levels that regulate the timing of spicule protraction and the success of male mating behavior.
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