H7BXZ5 · H7BXZ5_HUMAN
- Proteinnon-specific serine/threonine protein kinase
- GeneKALRN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2955 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | protein serine/threonine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH7BXZ5
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,321 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 650 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1683 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1710 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1719 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1722 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1725 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1726 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1741 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1742 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1768 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1773 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1786 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1806 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1835 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1866 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1882 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 2133 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2206 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2231 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2361 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2362 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2365 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-158 | CRAL-TRIO | ||||
Sequence: VLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH | ||||||
Region | 686-713 | Disordered | ||||
Sequence: LRSAPPSLGEPSEARDSAVSNNKTPHSS | ||||||
Compositional bias | 699-713 | Polar residues | ||||
Sequence: ARDSAVSNNKTPHSS | ||||||
Coiled coil | 897-924 | |||||
Sequence: NASSLSEAEQLQREHEQFQLAIEKTHQS | ||||||
Domain | 1250-1425 | DH | ||||
Sequence: KKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA | ||||||
Domain | 1437-1549 | PH | ||||
Sequence: NLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQ | ||||||
Region | 1563-1604 | Disordered | ||||
Sequence: LQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTS | ||||||
Compositional bias | 1586-1604 | Polar residues | ||||
Sequence: SQGDGSSQPDTISIASRTS | ||||||
Domain | 1615-1680 | SH3 | ||||
Sequence: GGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISHS | ||||||
Compositional bias | 1699-1742 | Polar residues | ||||
Sequence: HSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTS | ||||||
Region | 1699-1832 | Disordered | ||||
Sequence: HSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAAR | ||||||
Compositional bias | 1751-1773 | Basic and acidic residues | ||||
Sequence: KADGNIKKQKKVRDGRKSFDLGS | ||||||
Compositional bias | 1782-1806 | Basic and acidic residues | ||||
Sequence: PQGDSADEKSKKGWGEDEPDEESHT | ||||||
Region | 1869-1890 | Disordered | ||||
Sequence: DPAGCLNEGMAPPTPPKNPEEE | ||||||
Domain | 1898-2073 | DH | ||||
Sequence: GRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDM | ||||||
Domain | 2085-2195 | PH | ||||
Sequence: TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLE | ||||||
Region | 2214-2284 | Disordered | ||||
Sequence: ERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQN | ||||||
Compositional bias | 2255-2269 | Polar residues | ||||
Sequence: LPPLKISTSNGSPGF | ||||||
Domain | 2290-2355 | SH3 | ||||
Sequence: NGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTK | ||||||
Compositional bias | 2381-2403 | Basic and acidic residues | ||||
Sequence: AEVENTGKNEATGPRKPKDILGN | ||||||
Region | 2381-2423 | Disordered | ||||
Sequence: AEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDP | ||||||
Domain | 2440-2533 | Ig-like | ||||
Sequence: PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVK | ||||||
Domain | 2540-2634 | Fibronectin type-III | ||||
Sequence: APNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY | ||||||
Domain | 2653-2907 | Protein kinase | ||||
Sequence: YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL |
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,955
- Mass (Da)336,289
- Last updated2012-04-18 v1
- ChecksumCD1C4376D04CE4F4
Computationally mapped potential isoform sequences
There are 25 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O60229 | KALRN_HUMAN | KALRN | 2986 | ||
C9IZQ6 | C9IZQ6_HUMAN | KALRN | 1654 | ||
C9J1B4 | C9J1B4_HUMAN | KALRN | 194 | ||
A0A804HI83 | A0A804HI83_HUMAN | KALRN | 1092 | ||
A0A804HI91 | A0A804HI91_HUMAN | KALRN | 1022 | ||
A0A804HHT5 | A0A804HHT5_HUMAN | KALRN | 44 | ||
A0A804HI42 | A0A804HI42_HUMAN | KALRN | 103 | ||
A0A804HJ49 | A0A804HJ49_HUMAN | KALRN | 1041 | ||
A0A804HIN3 | A0A804HIN3_HUMAN | KALRN | 1000 | ||
A0A804HIP9 | A0A804HIP9_HUMAN | KALRN | 1005 | ||
A0A804HIY9 | A0A804HIY9_HUMAN | KALRN | 890 | ||
A0A804HJ74 | A0A804HJ74_HUMAN | KALRN | 189 | ||
A0A804HII1 | A0A804HII1_HUMAN | KALRN | 1198 | ||
A0A804HIK8 | A0A804HIK8_HUMAN | KALRN | 939 | ||
A0A0D9SGH1 | A0A0D9SGH1_HUMAN | KALRN | 53 | ||
A0A804HLI0 | A0A804HLI0_HUMAN | KALRN | 2986 | ||
A0A804HLC8 | A0A804HLC8_HUMAN | KALRN | 98 | ||
A0A804HLF3 | A0A804HLF3_HUMAN | KALRN | 1059 | ||
A0A804HJX0 | A0A804HJX0_HUMAN | KALRN | 545 | ||
A0A804HJZ3 | A0A804HJZ3_HUMAN | KALRN | 45 | ||
A0A804HJC5 | A0A804HJC5_HUMAN | KALRN | 1008 | ||
A0A804HKU9 | A0A804HKU9_HUMAN | KALRN | 145 | ||
A0A804HKT9 | A0A804HKT9_HUMAN | KALRN | 1613 | ||
A0A804HKJ7 | A0A804HKJ7_HUMAN | KALRN | 709 | ||
H7C1X7 | H7C1X7_HUMAN | KALRN | 215 |
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: X | ||||||
Compositional bias | 699-713 | Polar residues | ||||
Sequence: ARDSAVSNNKTPHSS | ||||||
Compositional bias | 1586-1604 | Polar residues | ||||
Sequence: SQGDGSSQPDTISIASRTS | ||||||
Compositional bias | 1699-1742 | Polar residues | ||||
Sequence: HSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTS | ||||||
Compositional bias | 1751-1773 | Basic and acidic residues | ||||
Sequence: KADGNIKKQKKVRDGRKSFDLGS | ||||||
Compositional bias | 1782-1806 | Basic and acidic residues | ||||
Sequence: PQGDSADEKSKKGWGEDEPDEESHT | ||||||
Compositional bias | 2255-2269 | Polar residues | ||||
Sequence: LPPLKISTSNGSPGF | ||||||
Compositional bias | 2381-2403 | Basic and acidic residues | ||||
Sequence: AEVENTGKNEATGPRKPKDILGN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC022336 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC069233 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC080008 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC112129 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC117381 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC117401 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF457679 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |