H7BXT3 · H7BXT3_HUMAN
- ProteinProprotein convertase subtilisin/kexin type 6
- GenePCSK6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids664 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 205 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 246 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 420 | Charge relay system | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | serine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH7BXT3
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 848 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Pro residues | ||||
Sequence: MPPRAPPAPGPRPPPR | ||||||
Region | 1-39 | Disordered | ||||
Sequence: MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGP | ||||||
Domain | 495-635 | P/Homo B | ||||
Sequence: AVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGDLETPVANQLTTEER |
Sequence similarities
Belongs to the peptidase S8 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length664
- Mass (Da)72,999
- Last updated2014-10-29 v2
- Checksum2F88205357942DB8
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P29122 | PCSK6_HUMAN | PCSK6 | 969 | ||
H0YMW5 | H0YMW5_HUMAN | PCSK6 | 125 | ||
H0YKK2 | H0YKK2_HUMAN | PCSK6 | 77 | ||
H0YLC8 | H0YLC8_HUMAN | PCSK6 | 126 | ||
H0YKZ4 | H0YKZ4_HUMAN | PCSK6 | 616 | ||
H0Y3Q0 | H0Y3Q0_HUMAN | PCSK6 | 797 | ||
A0A0J9YW51 | A0A0J9YW51_HUMAN | PCSK6 | 308 | ||
A0A7I2YQH5 | A0A7I2YQH5_HUMAN | PCSK6 | 849 | ||
A0A087WY68 | A0A087WY68_HUMAN | PCSK6 | 975 | ||
A0A087WZR0 | A0A087WZR0_HUMAN | PCSK6 | 962 | ||
A0A7I2V2Z7 | A0A7I2V2Z7_HUMAN | PCSK6 | 260 | ||
A0A7I2V3M4 | A0A7I2V3M4_HUMAN | PCSK6 | 538 | ||
A0A7I2V3T2 | A0A7I2V3T2_HUMAN | PCSK6 | 256 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Pro residues | ||||
Sequence: MPPRAPPAPGPRPPPR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC023024 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC087528 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090164 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AMYH02031172 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |