Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

H6WE97 · H6WE97_PANTR

  • Protein
    Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
  • Gene
    SAMHD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentsite of double-strand break
Cellular Componenttetraspanin-enriched microdomain
Molecular Functiondeoxynucleoside triphosphate hydrolase activity
Molecular FunctiondGTP binding
Molecular FunctiondGTPase activity
Molecular FunctionGTP binding
Molecular Functionidentical protein binding
Molecular FunctionRNA binding
Molecular FunctionRNA nuclease activity
Molecular Functionsingle-stranded DNA binding
Molecular Functionzinc ion binding
Biological ProcessdATP catabolic process
Biological Processdefense response to virus
Biological ProcessdGTP catabolic process
Biological ProcessDNA strand resection involved in replication fork processing
Biological Processdouble-strand break repair via homologous recombination
Biological Processnegative regulation of type I interferon-mediated signaling pathway
Biological Processprotein homotetramerization
Biological Processregulation of innate immune response
Biological Processsomatic hypermutation of immunoglobulin genes

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Gene names

    • Name
      SAMHD1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    H6WE97
  • Secondary accessions
    • A0A2J8MKX9
    • H2QKA9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-18Basic and acidic residues
Region1-35Disordered
Domain45-110SAM
Domain164-316HD

Sequence similarities

Belongs to the SAMHD1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    626
  • Mass (Da)
    72,224
  • Last updated
    2012-04-18 v1
  • MD5 Checksum
    27D65B77A13C3A5CE39EE30D5F719BE9
MQRADSEQPSKRPRCDDSPRTPSNTPSAEADWSPGLELHPDYKTWGPEQVCSFLRRGGFEELVLLKNIRENEITGALLPCLDESRFENLGVSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALGEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQHFVQWCADRNFTKPQDGDVIAPLITPQKKEWNDSTSVQNPTRLREASKSRVQLFKDDPM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACZ04052781
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
JQ231123
EMBL· GenBank· DDBJ
AFB71157.1
EMBL· GenBank· DDBJ
mRNA
JQ085410
EMBL· GenBank· DDBJ
AFJ79636.1
EMBL· GenBank· DDBJ
mRNA
JQ085411
EMBL· GenBank· DDBJ
AFJ79637.1
EMBL· GenBank· DDBJ
mRNA
JN936887
EMBL· GenBank· DDBJ
AFU88758.1
EMBL· GenBank· DDBJ
mRNA
GABF01006234
EMBL· GenBank· DDBJ
JAA15911.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help