H6UP83 · H6UP83_LOXCY

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COX2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Lope1
    • Tai1
    • DS1511
    • LO3505
    • LO3508
    • DS1510
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Afrotheria > Proboscidea > Elephantidae > Loxodonta

Accessions

  • Primary accession
    H6UP83

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-51Helical
Transmembrane63-87Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Cytochrome oxidase subunit II transmembrane region profile
Domain92-225Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    26,022
  • Last updated
    2012-04-18 v1
  • Checksum
    61579D7CC957AA25
MAYPLQLGFQDATSPVMEELLHFHDHTLMIIFLISSLVLYIIMLMLTSKLIHTNMMNVQEMEMIWTILPAIILILIALPSLHTLYMMDEINNPLLTIKTMGHQWFWSYEYTDYEDLAFDSYMITTDSLKFGELRLLEVDNRMVLPTDLPIRVLVSSEDVLHSWAVPSLGLKTDAIPGRLNQVTLTSMRPGLFYGQCSEICGANHSFMPIVLELVPLKYFESWSASLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN673263
EMBL· GenBank· DDBJ
AEQ59291.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ557423
EMBL· GenBank· DDBJ
AHW57954.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ557424
EMBL· GenBank· DDBJ
AHW57967.1
EMBL· GenBank· DDBJ
Genomic DNA
KY616975
EMBL· GenBank· DDBJ
AQY56363.1
EMBL· GenBank· DDBJ
Genomic DNA
KY616976
EMBL· GenBank· DDBJ
AQY56376.1
EMBL· GenBank· DDBJ
Genomic DNA
KY616978
EMBL· GenBank· DDBJ
AQY56402.1
EMBL· GenBank· DDBJ
Genomic DNA
KY616979
EMBL· GenBank· DDBJ
AQY56415.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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