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H6QY63 · H6QY63_NOCCG

Function

function

Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.

GO annotations

AspectTerm
Molecular FunctionL-serine ammonia-lyase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionthreonine deaminase activity
Biological Processisoleucine biosynthetic process
Biological ProcessL-serine catabolic process
Biological Processthreonine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-threonine dehydratase
  • EC number
  • Alternative names
    • Threonine deaminase

Gene names

    • Name
      ilvA
    • Ordered locus names
      NOCYR_1923

Organism names

Accessions

  • Primary accession
    H6QY63

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain367-441ACT-like

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    47,266
  • Last updated
    2012-04-18 v1
  • MD5 Checksum
    2A7AF2F5F8DCB5EA681BE32E7A3CCC8D
MSDPVDVLAELPTRPPLNADEIDAAAKRISDIIDPTPLQLCPRLSQLTGAQVYLKREDLTVVRSYKLRGAYNLVVQLSELERAAGVVTASAGNHAQGVAFACKAMGINGRIYVPTTTPKQKRDRIRIHGGEFVELIAVGETYDAAAAAAAADVARTGATMVPPFDDTRTAAGQGTIAAEILDQLGRTPDLVVVPVGGGGCLAGIGTYLRERSPRTAILGVEPAGAASMTAALVAGGPVTLPEIDPFVDGAAVRRIGDVPYAAVSGFGGRVVSHGSLPLLVATESPSGAGSFRMMQVDEGAICTAMLDLYQNEGIIAEPAGALAVTALAGLDIEPGSTVVCLVSGGNNDVSRYGEVIERSLVHQGLKHYFLVDFPQEPGALRRFLDEVLGPDDDITLFEYVKRNNRETGAALVGIELGAPEELESLLARIDASPIQCERLEPDSPAYRYLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO082843
EMBL· GenBank· DDBJ
CCF62709.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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