H3K2X4 · H3K2X4_9EURO

Function

function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionsqualene monooxygenase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Squalene monooxygenase
  • EC number

Gene names

    • Name
      erg1
    • Synonyms
      SQLE

Organism names

  • Taxonomic identifier
  • Strains
    • TIMM2789
    • TMH1
    • TMH2
    • TMH3
    • TMH4
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton

Accessions

  • Primary accession
    H3K2X4

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Microsome membrane
; Multi-pass membrane protein

Keywords

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-31Disordered
Domain40-70FAD dependent oxidoreductase
Domain191-404Squalene epoxidase

Sequence similarities

Belongs to the squalene monooxygenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    45,166
  • Last updated
    2012-04-18 v1
  • Checksum
    D455371447E391B4
MVVEAPPCPQSGNGFANGSAKPKAYRDEAERRRYEHHEADVVIIGAGIAGCALAVALGNQGRSVILLERSLKEPDRIVGELLQPGGVRALEQLGLRDCLEGIDAVRTYGYDVIYFGNGVKIPFPSDANDKILEGRCFHHGRFIMRLREAAAANPNVTIVETKAVSTIKSTHTGDVLGVQCQTDGKQDFYFGPLTVVADGYASTFRKEYLPIQPVAKSKFWGLELIDAKLPIPGHGHVVLGDFPPILIYQIGEHETRILIDIPDNLPSASVANGGVKGHMRNVVLPSLPECIRPSFEAALEKGGFRSMPNSFLRPVTNRIPGLMFLGDSLNMRHPLTGGGMTVAFNDVVLLRNLLSPEAVPDLSDTKLVLKQLSKFHWQRKSLISVINILAQSLYSIFAAGGKHMFSLPLLLVSGY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB690298
EMBL· GenBank· DDBJ
BAL48859.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130516
EMBL· GenBank· DDBJ
QOH97037.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130517
EMBL· GenBank· DDBJ
QOH97038.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130518
EMBL· GenBank· DDBJ
QOH97039.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130519
EMBL· GenBank· DDBJ
QOH97040.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130520
EMBL· GenBank· DDBJ
QOH97041.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130521
EMBL· GenBank· DDBJ
QOH97042.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130522
EMBL· GenBank· DDBJ
QOH97043.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130523
EMBL· GenBank· DDBJ
QOH97044.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130524
EMBL· GenBank· DDBJ
QOH97045.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130525
EMBL· GenBank· DDBJ
QOH97046.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130526
EMBL· GenBank· DDBJ
QOH97047.1
EMBL· GenBank· DDBJ
Genomic DNA
MT130527
EMBL· GenBank· DDBJ
QOH97048.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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