H3GHV1 · H3GHV1_PHYRM
- ProteinPentafunctional AROM polypeptide
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1547 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Catalytic activity
- 3-dehydroquinate = 3-dehydroshikimate + H2O
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate dehydratase activity | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | 3-phosphoshikimate 1-carboxyvinyltransferase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePentafunctional AROM polypeptide
Including 5 domains:
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
- Recommended name3-phosphoshikimate 1-carboxyvinyltransferase
- EC number
- Recommended nameShikimate kinase
- EC number
- Short namesSK
- Recommended name3-dehydroquinate dehydratase
- EC number
- Short names3-dehydroquinase
- Recommended nameShikimate dehydrogenase
- EC number
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora
Accessions
- Primary accessionH3GHV1
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 78-336 | 3-dehydroquinate synthase | ||||
Sequence: AIPSGEASKCREMKAKIEDEVLFPNRCHRDTCIVAVGGGVVGDLSGYVASTYMRGVPFVQVPTSLLACVDSSIGGKTGIDVEAGKNLLGAFHMPQRVYIDLSVLHTLPKRELINGMGEVVKSGAIFNAELFELLETSAESILALSDMDLVQRVVALTVQVKATVVTQDTKEMGLRAILNFGHSIGHGIEALVQPEYLHGECVSMGCIKEAEIARGMGVCSSATVGRLRRCLASYGLPVRVPEHVATRDVLVKMEVDKKN | ||||||
Domain | 379-803 | Enolpyruvate transferase | ||||
Sequence: GAKANGTIRVPGSKSISNRVLLMAALGKGACRITGLLHSDDTQVMMTALQKVGAKFSWEDNGAVLVVEGTAGKFATVADGEEIYLSNAGTAARFLTSAMTLVPSENDGTVVVTGNYRMKERPIAPLVEALRGNGCDISYLETEGCPPLAIRGTGLRGGTVRLAAKVSSQYVSSVLISAPYAKEPLVLELDEEQPTSLPYILMTTQLMQQFGIPVETLAPNRYRVPCGVYENPKEVSVEVDASSATYPLAFAAITGGQVTVEALGNTSLQGDAAFHTLLRSMGCTTTQDATSTTVIGPQDGTPLKAVDIDMETMTDAFMTAVALAAVADGTTKITGIANQRVKECNRIEVMVTELHKIGVECGELPDGIWIKGTAGKTDHLKQASIACHNDHRIAMSFAVLGSVVGNVVITDKECTDKTYPEFWDH | ||||||
Domain | 1259-1343 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: LFGSPIQKSPSPAMHNAGFESTSLSSLFTYGLHDTTDVLEIVKRMQAPDTCFGGGSVTIPLKVDIMAHLNELSPAARAIGAVNTI | ||||||
Domain | 1382-1456 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | ||||
Sequence: HELTALVVGAGGTSMAASYAMRQLGVGKLFIFNRTLEKAQAVAARFDAEALSELTPETLAQVDVVVGTIPAQAGF |
Sequence similarities
Belongs to the EPSP synthase family.
In the 2nd section; belongs to the EPSP synthase family.
In the 2nd section; belongs to the type-I 3-dehydroquinase family.
In the 3rd section; belongs to the shikimate kinase family.
In the 4th section; belongs to the type-I 3-dehydroquinase family.
In the C-terminal section; belongs to the shikimate dehydrogenase family.
In the N-terminal section; belongs to the dehydroquinate synthase family.
In the N-terminal section; belongs to the shikimate kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,547
- Mass (Da)167,786
- Last updated2012-04-18 v1
- ChecksumD72E5013C3470CEC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS566010 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |