H3BR82 · H3BR82_HUMAN
- ProteinProtein spinster homolog 1
- GeneSPNS1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids538 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H+(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H+(in)
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H+(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H+(in)
- a 1-acyl-sn-glycero-3-phosphocholine(out) + H+(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H+(in)
- a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H+(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein spinster homolog 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH3BR82
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 88-108 | Helical | ||||
Sequence: LIQTVFISSYMVLAPVFGYLG | ||||||
Transmembrane | 115-134 | Helical | ||||
Sequence: YLMCGGIAFWSLVTLGSSFI | ||||||
Transmembrane | 154-170 | Helical | ||||
Sequence: ASYSTIAPTLIADLFVA | ||||||
Transmembrane | 177-195 | Helical | ||||
Sequence: LSIFYFAIPVGSGLGYIAG | ||||||
Transmembrane | 215-232 | Helical | ||||
Sequence: QVTPGLGVVAVLLLFLVV | ||||||
Transmembrane | 267-288 | Helical | ||||
Sequence: FVLSSLGFTAVAFVTGSLALWA | ||||||
Transmembrane | 317-338 | Helical | ||||
Sequence: LIFGLITCLTGVLGVGLGVEIS | ||||||
Transmembrane | 350-369 | Helical | ||||
Sequence: PLVCATGLLGSAPFLFLSLA | ||||||
Transmembrane | 375-405 | Helical | ||||
Sequence: IVATYIFIFIGETLLSMNWAIVADILLYVVI |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 500 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: QADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQ | ||||||
Domain | 50-538 | Major facilitator superfamily (MFS) profile | ||||
Sequence: IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRPSVSQVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLACCTKQGPQTTGLWCPSGAAPPACPWPVCSSERLPLTYLHICHSWPWAHPTKGLGLTPWPGPASRGTLGRVPAPRHYLGSSGEEVGVQEGDPSPQGQPQGLGAI | ||||||
Region | 499-538 | Disordered | ||||
Sequence: RGTLGRVPAPRHYLGSSGEEVGVQEGDPSPQGQPQGLGAI |
Sequence similarities
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length538
- Mass (Da)57,191
- Last updated2012-04-18 v1
- ChecksumCAF823DE6CBF50A2
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Q | ||||||
Non-terminal residue | 538 | |||||
Sequence: I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC109460 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |