H3BPJ7 · H3BPJ7_HUMAN
- ProteinTranscription factor 4
- GeneTCF4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids642 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | protein dimerization activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscription factor 4
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionH3BPJ7
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 945 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 42 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 63 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 68 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 115 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 173 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 272 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 287 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 292 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 293 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 308 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 315 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 317 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 318 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 322 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 326 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 345 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 346 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 347 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 350 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 458 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 459 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 485 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 490 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 518 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 521 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-41 | Polar residues | ||||
Sequence: MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHP | ||||||
Region | 1-220 | Disordered | ||||
Sequence: MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNS | ||||||
Compositional bias | 62-99 | Polar residues | ||||
Sequence: GSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQ | ||||||
Compositional bias | 114-135 | Polar residues | ||||
Sequence: LSPTKPGSQYYQYSSNNPRRRP | ||||||
Compositional bias | 159-220 | Polar residues | ||||
Sequence: VYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNS | ||||||
Compositional bias | 256-294 | Polar residues | ||||
Sequence: STFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQ | ||||||
Region | 256-296 | Disordered | ||||
Sequence: STFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTG | ||||||
Region | 311-354 | Disordered | ||||
Sequence: HTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPL | ||||||
Region | 441-545 | Disordered | ||||
Sequence: SLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANN | ||||||
Compositional bias | 444-463 | Polar residues | ||||
Sequence: PNQVPVPQLPVQSATSPDLN | ||||||
Compositional bias | 488-545 | Basic and acidic residues | ||||
Sequence: IKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANN | ||||||
Domain | 539-592 | BHLH | ||||
Sequence: ERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSL | ||||||
Region | 609-642 | Disordered | ||||
Sequence: KRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length642
- Mass (Da)68,483
- Last updated2012-04-18 v1
- Checksum3FB2B751A05C33A6
Computationally mapped potential isoform sequences
There are 48 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P15884 | ITF2_HUMAN | TCF4 | 667 | ||
A0A075B723 | A0A075B723_HUMAN | TCF4 | 209 | ||
G0LNT4 | G0LNT4_HUMAN | TCF4 | 139 | ||
G0LNT7 | G0LNT7_HUMAN | TCF4 | 119 | ||
A0A0E3D6N2 | A0A0E3D6N2_HUMAN | TCF4 | 65 | ||
A0A6Q8PGE3 | A0A6Q8PGE3_HUMAN | TCF4 | 64 | ||
H3BUQ3 | H3BUQ3_HUMAN | TCF4 | 146 | ||
H3BTP3 | H3BTP3_HUMAN | TCF4 | 677 | ||
H3BTM9 | H3BTM9_HUMAN | TCF4 | 134 | ||
H3BTZ0 | H3BTZ0_HUMAN | TCF4 | 280 | ||
H3BT24 | H3BT24_HUMAN | TCF4 | 287 | ||
H3BTC3 | H3BTC3_HUMAN | TCF4 | 158 | ||
H3BT95 | H3BT95_HUMAN | TCF4 | 168 | ||
H3BRF7 | H3BRF7_HUMAN | TCF4 | 179 | ||
H3BPG3 | H3BPG3_HUMAN | TCF4 | 162 | ||
H3BP59 | H3BP59_HUMAN | TCF4 | 165 | ||
H3BNI2 | H3BNI2_HUMAN | TCF4 | 56 | ||
H3BNZ2 | H3BNZ2_HUMAN | TCF4 | 163 | ||
H3BMC8 | H3BMC8_HUMAN | TCF4 | 135 | ||
H3BME8 | H3BME8_HUMAN | TCF4 | 124 | ||
H3BML7 | H3BML7_HUMAN | TCF4 | 61 | ||
A0A1B0GVB8 | A0A1B0GVB8_HUMAN | TCF4 | 631 | ||
A0A1B0GUT3 | A0A1B0GUT3_HUMAN | TCF4 | 50 | ||
A0A1B0GV10 | A0A1B0GV10_HUMAN | TCF4 | 99 | ||
A0A1B0GTP2 | A0A1B0GTP2_HUMAN | TCF4 | 102 | ||
A0A1B0GXH5 | A0A1B0GXH5_HUMAN | TCF4 | 118 | ||
A0A1B0GWD5 | A0A1B0GWD5_HUMAN | TCF4 | 541 | ||
A0A1B0GW91 | A0A1B0GW91_HUMAN | TCF4 | 455 | ||
A0A1B0GVR6 | A0A1B0GVR6_HUMAN | TCF4 | 680 | ||
A0A0D9SEK1 | A0A0D9SEK1_HUMAN | TCF4 | 224 | ||
A0A0D9SF18 | A0A0D9SF18_HUMAN | TCF4 | 202 | ||
A0A0D9SGH7 | A0A0D9SGH7_HUMAN | TCF4 | 81 | ||
A0A0D9SGJ4 | A0A0D9SGJ4_HUMAN | TCF4 | 134 | ||
A0A0D9SG78 | A0A0D9SG78_HUMAN | TCF4 | 315 | ||
A0A0D9SFX5 | A0A0D9SFX5_HUMAN | TCF4 | 228 | ||
A0A0D9SFZ1 | A0A0D9SFZ1_HUMAN | TCF4 | 80 | ||
A0A0D9SGE4 | A0A0D9SGE4_HUMAN | TCF4 | 135 | ||
A0A0D9SGE5 | A0A0D9SGE5_HUMAN | TCF4 | 221 | ||
A0A0D9SGE7 | A0A0D9SGE7_HUMAN | TCF4 | 128 | ||
A0A0D9SG44 | A0A0D9SG44_HUMAN | TCF4 | 81 | ||
A0A0D9SFU5 | A0A0D9SFU5_HUMAN | TCF4 | 207 | ||
A0A0D9SG55 | A0A0D9SG55_HUMAN | TCF4 | 156 | ||
A0A0D9SG61 | A0A0D9SG61_HUMAN | TCF4 | 204 | ||
A0A0D9SEX8 | A0A0D9SEX8_HUMAN | TCF4 | 179 | ||
A0A0D9SEZ3 | A0A0D9SEZ3_HUMAN | TCF4 | 236 | ||
A0A0D9SF97 | A0A0D9SF97_HUMAN | TCF4 | 155 | ||
E9PH57 | E9PH57_HUMAN | TCF4 | 773 | ||
K7ESI6 | K7ESI6_HUMAN | TCF4 | 166 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-41 | Polar residues | ||||
Sequence: MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHP | ||||||
Compositional bias | 62-99 | Polar residues | ||||
Sequence: GSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQ | ||||||
Compositional bias | 114-135 | Polar residues | ||||
Sequence: LSPTKPGSQYYQYSSNNPRRRP | ||||||
Compositional bias | 159-220 | Polar residues | ||||
Sequence: VYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNS | ||||||
Compositional bias | 256-294 | Polar residues | ||||
Sequence: STFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQ | ||||||
Compositional bias | 444-463 | Polar residues | ||||
Sequence: PNQVPVPQLPVQSATSPDLN | ||||||
Compositional bias | 488-545 | Basic and acidic residues | ||||
Sequence: IKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC013587 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC018994 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090383 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090684 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC091103 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF459816 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |